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5J13
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BU of 5j13 by Molmil
Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)
Descriptor: SULFATE ION, Thymic stromal lymphopoietin, anti-TSLP Fab-fragment, ...
Authors:Verstraete, K, Savvides, S.N.
Deposit date:2016-03-28
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Nat Commun, 8, 2017
5J11
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BU of 5j11 by Molmil
Structure of human TSLP in complex with TSLPR and IL-7Ralpha
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, ...
Authors:Verstraete, K, Savvides, S.N.
Deposit date:2016-03-28
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Nat Commun, 8, 2017
3Q0W
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BU of 3q0w by Molmil
ETHR From mycobacterium tuberculosis in complex with compound BDM33066
Descriptor: (2S)-2-amino-3-methyl-1-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one, GLYCEROL, HTH-type transcriptional regulator EthR
Authors:Flipo, M, Desrose, M, Dirie, B, Carette, X, Leroux, F, Lens, Z, Rucktooa, P, Piveteau, C, Demirkaya, F, Locht, C, Villeret, V, Christophe, T, Jeon, H.K, Brodin, P, Deprez, B, Baulard, A, Willand, N.
Deposit date:2010-12-16
Release date:2011-12-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.
Nucleic Acids Res., 40, 2012
4QL0
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BU of 4ql0 by Molmil
Crystal Structure Analysis of the Membrane Transporter FhaC (double mutant V169T, I176N)
Descriptor: DI(HYDROXYETHYL)ETHER, Filamentous hemagglutinin transporter protein FhaC, HEXAETHYLENE GLYCOL, ...
Authors:Maier, T, Clantin, B, Gruss, F, Dewitte, F, Delattre, A.S, Jacob-Dubuisson, F, Hiller, S, Villeret, V.
Deposit date:2014-06-10
Release date:2015-06-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conserved Omp85 lid-lock structure and substrate recognition in FhaC
Nat Commun, 6, 2015
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