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Crystal structure of human FPPS in complex with salicylic acid derivative 3a
Descriptor:	2-(naphthalen-1-ylmethoxy)benzoic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:	Rondeau, J.M, Bourgier, E, Lehmann, S.
Deposit date:	2015-09-01
Release date:	2015-09-30
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015

Crystal structure of human FPPS in complex with biaryl compound 5
Descriptor:	4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION
Authors:	Rondeau, J.M, Bourgier, E, Lehmann, S.
Deposit date:	2015-09-02
Release date:	2015-09-30
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015

Crystal structure of human FPPS in complex with biaryl compound 8e
Descriptor:	8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase
Authors:	Rondeau, J.M, Bourgier, E, Lehmann, S.
Deposit date:	2015-09-02
Release date:	2015-10-07
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015

Crystal structure of human FPPS in complex with biaryl compound 6
Descriptor:	1H,1'H-4,4'-biindole-2-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:	Rondeau, J.M, Bourgier, E, Lehmann, S.
Deposit date:	2015-09-02
Release date:	2015-09-30
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015