3B25
| Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 | Descriptor: | 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
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7F4X
| Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | Authors: | Yokoyama, T, Ostermann, A, Schrader, T.E. | Deposit date: | 2021-06-21 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION | Cite: | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
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3B26
| Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 | Descriptor: | 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
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1V3W
| Structure of Ferripyochelin binding protein from Pyrococcus horikoshii OT3 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Jeyakanthan, J, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-11-07 | Release date: | 2003-11-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii. Acta Crystallogr.,Sect.D, 64, 2008
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5YY9
| Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Ligase 1 | Authors: | Kori, S, Defossez, P.A, Arita, K. | Deposit date: | 2017-12-08 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.653 Å) | Cite: | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
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1V67
| Structure of ferripyochelin binding protein from pyrococcus horikoshii OT3 | Descriptor: | BICARBONATE ION, CALCIUM ION, ZINC ION, ... | Authors: | Jeyakanthan, J, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-11-27 | Release date: | 2003-12-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii. Acta Crystallogr.,Sect.D, 64, 2008
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5YYA
| Crystal structure of Tandem Tudor Domain of human UHRF1 | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION | Authors: | Kori, S, Defossez, P.A, Arita, K. | Deposit date: | 2017-12-08 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
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7XEJ
| SufS with D-cysteine for 5 min | Descriptor: | (2~{S})-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-sulfanyl-propanoic acid, 1,2-ETHANEDIOL, Cysteine desulfurase SufS, ... | Authors: | Nakamiura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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7XES
| NifS with L-penicillamine | Descriptor: | (2~{R})-3-methyl-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-sulfanyl-butanoic acid, CHLORIDE ION, Cysteine desulfurase IscS, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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7XEK
| SufS with D-cysteine for 6 h | Descriptor: | (2~{S},4~{S})-2-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, Cysteine desulfurase SufS, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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7XEN
| SufS with L-penicillamine | Descriptor: | (2~{R})-3-methyl-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-sulfanyl-butanoic acid, Cysteine desulfurase SufS | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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7XET
| SufS with beta-cyano-L-alanine | Descriptor: | (2~{E})-3-cyano-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylimino]propanoic acid, Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Inhibition mechanism of SufS by L-propargylglycine to be published
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7XEP
| SufS with L-propargylglycine | Descriptor: | 1,2-ETHANEDIOL, Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Inhibition mechanism of SufS by L-propargylglycine to be published
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7XEQ
| NifS with D-cysteine | Descriptor: | (2~{S},4~{S})-2-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, Cysteine desulfurase IscS, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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7XEL
| SufS soaked with D-penicillamine | Descriptor: | 1,2-ETHANEDIOL, Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-03-31 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published
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5ZJG
| Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with Gly-Gly | Descriptor: | GLYCEROL, GLYCINE, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03 L-subunit, ... | Authors: | Hibi, T, Imaoka, M, Itoh, T, Wakayama, M. | Deposit date: | 2018-03-20 | Release date: | 2019-01-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Crystal structure analysis and enzymatic characterization of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens. Biosci. Biotechnol. Biochem., 83, 2019
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3B28
| Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765 | Descriptor: | 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, GLYCEROL, Heat shock protein HSP 90-alpha, ... | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
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3WHX
| Crystal structure of anti-prostaglandin E2 Fab fragment PGE1 complex | Descriptor: | 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, mAb Fab H fragment, mAb Fab L fragment | Authors: | Sugahara, M, Ago, H, Saino, H, Miyano, M. | Deposit date: | 2013-09-03 | Release date: | 2014-09-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of anti-Prostaglandin E2 Fab fragment with Prostaglandin E2 To be Published
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7YB3
| SufS with D-cysteine for 1 min | Descriptor: | Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL | Authors: | Nakamura, R, Fujishiro, T. | Deposit date: | 2022-06-28 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Snapshots of thiazolidine fomration of PLP-dependent enzyme SufS to be published
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3WFH
| Crystal structure of anti-Prostaglandin E2 Fab fragment PGE2 complex | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, mAb Fab H fragment, mAb Fab L fragment | Authors: | Sugahara, M, Ago, H, Saino, H, Miyano, M. | Deposit date: | 2013-07-19 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of anti-Prostaglandin E2 Fab fragment with Prostaglandin E2 To be Published
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3ADE
| Crystal Structure of Keap1 in Complex with Sequestosome-1/p62 | Descriptor: | Kelch-like ECH-associated protein 1, SULFATE ION, Sequestosome-1 | Authors: | Kurokawa, H, Yamamoto, M. | Deposit date: | 2010-01-19 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat.Cell Biol., 12, 2010
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1VCK
| Crystal structure of ferredoxin component of carbazole 1,9a-dioxygenase of Pseudomonas resinovorans strain CA10 | Descriptor: | FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, HYDROSULFURIC ACID, ... | Authors: | Nam, J.-W, Noguchi, H, Fujiomoto, Z, Mizuno, H, Fushinobu, S, Kobashi, N, Iwata, K, Yoshida, T, Habe, H, Yamane, H, Omori, T, Nojiri, H. | Deposit date: | 2004-03-09 | Release date: | 2005-03-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the ferredoxin component of carbazole 1,9a-dioxygenase of Pseudomonas resinovorans strain CA10, a novel Rieske non-heme iron oxygenase system PROTEINS, 58, 2005
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7Y3J
| 24B3 antibody-peptide complex | Descriptor: | 24B3 Heavy chain, 24B3 Light chain, ALA-LEU-VAL-PHE-PHE-ALA-PRO-ALA-VAL-GLY-SER | Authors: | Irie, K, Irie, Y, Kita, A, Miki, K. | Deposit date: | 2022-06-11 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of the 24B3 antibody against the toxic conformer of amyloid beta with a turn at positions 22 and 23. Biochem.Biophys.Res.Commun., 621, 2022
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2ZXX
| Crystal structure of Cdt1/geminin complex | Descriptor: | DNA replication factor Cdt1, Geminin | Authors: | Cho, Y, Lee, C, Hong, B.S, Choi, J.M. | Deposit date: | 2009-01-08 | Release date: | 2009-02-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for inhibition of the replication licensing factor Cdt1 by geminin Nature, 430, 2004
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3A4D
| Crystal structure of Human Transthyretin (wild-type) | Descriptor: | GLYCEROL, SULFATE ION, Transthyretin | Authors: | Miyata, M. | Deposit date: | 2009-07-06 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Role of the Glutamic Acid 54 Residue in Transthyretin Stability and Thyroxine Binding Biochemistry, 2009
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