5IB8
 
 | | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2016-02-22 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | The ribosome prohibits the GU wobble geometry at the first position of the codon-anticodon helix.
Nucleic Acids Res., 44, 2016
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6YEF
 | | 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S11, ... | | 著者 | Fatkhullin, B, Golubev, A, Khusainov, I, Yusupova, G, Yusupov, M. | | 登録日 | 2020-03-24 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 angstrom resolution.
Febs Lett., 594, 2020
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7Q08
 | | Structure of Candida albicans 80S ribosome in complex with cycloheximide | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-14 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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7Q0R
 | | Structure of the Candida albicans 80S ribosome in complex with blasticidin s | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ... | | 著者 | Kolosova, O, Zgadzay, Y, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-16 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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4WRA
 | | Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-10-23 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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4WU1
 | | Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-10-30 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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4WSD
 | | Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-10-27 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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4WZD
 | | Complex of 70S ribosome with cognate tRNA-Tyr in the P-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-11-19 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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4U53
 | | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | | 分子名称: | (3beta,7alpha)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U4O
 | | Crystal structure of Geneticin bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U4R
 | | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U51
 | | Crystal structure of Narciclasine bound to the yeast 80S ribosome | | 分子名称: | (2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U52
 | | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U4N
 | | Crystal structure of Edeine bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U3M
 | | Crystal structure of Anisomycin bound to the yeast 80S ribosome | | 分子名称: | 18S rRNA, 25s rRNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-22 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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8OEQ
 | | Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM) | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Kolosova, O, Zgadzay, Y, Yusupov, M. | | 登録日 | 2023-03-12 | | 公開日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
To Be Published
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8P4V
 | | 80S yeast ribosome in complex with HaterumaimideQ | | 分子名称: | (3~{R})-3-[(1~{S})-2-[(1~{R},3~{S},4~{a}~{S},8~{a}~{S})-5,5,8~{a}-trimethyl-2-methylidene-3-oxidanyl-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Terrosu, S, Yusupov, M. | | 登録日 | 2023-05-23 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | | 主引用文献 | Role of Protein eL42 in the Ribosome Binding of Synthetic Analogues of Natural Lissoclimides
To Be Published
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5TBW
 | | Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D. | | 登録日 | 2016-09-13 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
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5DAT
 | | Complex of yeast 80S ribosome with hypusine-containing eIF5A | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | | 登録日 | 2015-08-20 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
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5IB7
 | | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2016-02-22 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | The ribosome prohibits the GU wobble geometry at the first position of the codon-anticodon helix.
Nucleic Acids Res., 44, 2016
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7Q0F
 | | Structure of Candida albicans 80S ribosome in complex with phyllanthoside | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-14 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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7PZY
 | | Structure of the vacant Candida albicans 80S ribosome | | 分子名称: | 1,4-DIAMINOBUTANE, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-13 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.32 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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7Q0P
 | | Structure of the Candida albicans 80S ribosome in complex with anisomycin | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ... | | 著者 | Kolosova, O, Zgadzay, Y, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-15 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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5IBB
 | | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2016-02-22 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | The ribosome prohibits the GU wobble geometry at the first position of the codon-anticodon helix.
Nucleic Acids Res., 44, 2016
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7OSA
 | | Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands | | 分子名称: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0, ... | | 著者 | Djumagulov, M, Jenner, L, Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2021-06-08 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Accuracy mechanism of eukaryotic ribosome translocation.
Nature, 600, 2021
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