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2ITO
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BU of 2ito by Molmil
Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, Gefitinib
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITU
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BU of 2itu by Molmil
Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941
分子名称: 1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2JIU
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BU of 2jiu by Molmil
Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788
分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Mengwasser, K.E, Toms, A.V, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日2007-07-01
公開日2008-01-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP.
Proc.Natl.Acad.Sci.USA, 105, 2008
2JIT
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BU of 2jit by Molmil
Crystal structure of EGFR kinase domain T790M mutation
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Mengwasser, K.E, Toms, A.V, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日2007-07-01
公開日2008-01-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP.
Proc.Natl.Acad.Sci.USA, 105, 2008
2JIV
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BU of 2jiv by Molmil
Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
分子名称: CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide
著者Yun, C.-H, Mengwasser, K.E, Toms, A.V, Li, Y, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日2007-07-02
公開日2008-01-22
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP.
Proc.Natl.Acad.Sci.USA, 105, 2008
2ITY
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BU of 2ity by Molmil
Crystal structure of EGFR kinase domain in complex with Iressa
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, Gefitinib
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITP
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BU of 2itp by Molmil
Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788
分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITW
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BU of 2itw by Molmil
Crystal structure of EGFR kinase domain in complex with AFN941
分子名称: 1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITQ
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BU of 2itq by Molmil
Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
分子名称: 1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITV
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BU of 2itv by Molmil
Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITT
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BU of 2itt by Molmil
Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788
分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2J6M
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BU of 2j6m by Molmil
Crystal structure of EGFR kinase domain in complex with AEE788
分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-09-29
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITN
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BU of 2itn by Molmil
Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITZ
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BU of 2itz by Molmil
Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa
分子名称: CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, Gefitinib
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2ITX
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BU of 2itx by Molmil
Crystal structure of EGFR kinase domain in complex with AMP-PNP
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2J5E
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BU of 2j5e by Molmil
Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab
分子名称: CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Eck, M.J.
登録日2006-09-14
公開日2007-02-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics.
Nat.Chem.Biol., 3, 2007
2J5F
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BU of 2j5f by Molmil
Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
著者Yun, C.-H, Eck, M.J.
登録日2006-09-14
公開日2007-02-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics.
Nat.Chem.Biol., 3, 2007
1ZMF
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BU of 1zmf by Molmil
C domain of human cyclophilin-33(hcyp33)
分子名称: Peptidyl-prolyl cis-trans isomerase E
著者Wang, T, Yun, C.-H, Gu, S.-Y, Chang, W.-R, Liang, D.-C.
登録日2005-05-10
公開日2005-08-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献1.88A crystal structure of the C domain of hCyP33: A novel domain of peptidyl-prolyl cis-trans isomerase
Biochem.Biophys.Res.Commun., 333, 2005
5D41
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BU of 5d41 by Molmil
EGFR kinase domain in complex with mutant selective allosteric inhibitor
分子名称: (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Yun, C.-H, Park, E, Eck, M.J.
登録日2015-08-07
公開日2016-06-08
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature, 534, 2016
3IKA
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BU of 3ika by Molmil
Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002
分子名称: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
著者Yun, C.-H, Eck, M.J.
登録日2009-08-05
公開日2010-01-12
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature, 462, 2009
7YQC
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BU of 7yqc by Molmil
EM structure of human PA28gamma
分子名称: Proteasome activator complex subunit 3
著者Chen, D.-D, Hao, J, Shen, C.-H, Yun, C.-H.
登録日2022-08-06
公開日2022-09-21
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Atomic resolution Cryo-EM structure of human proteasome activator PA28 gamma.
Int.J.Biol.Macromol., 219, 2022
7YQD
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BU of 7yqd by Molmil
EM structure of human PA28gamma (wild-type)
分子名称: Proteasome activator complex subunit 3
著者Chen, D.-D, Hao, J, Yun, C.-H.
登録日2022-08-06
公開日2022-09-21
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Atomic resolution Cryo-EM structure of human proteasome activator PA28 gamma.
Int.J.Biol.Macromol., 219, 2022

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