2JW2
 
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2L3D
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2KR7
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2KSN
 | | Solution Structure of the N-terminal Domain of DC-UbP/UBTD2 | | 分子名称: | Ubiquitin domain-containing protein 2 | | 著者 | Song, A, Zhou, C, Guan, X, Sze, K, Hu, H. | | 登録日 | 2010-01-08 | | 公開日 | 2010-05-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin
Protein Sci., 19, 2010
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2LXW
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4IDP
 | | human atlastin-1 1-446, N440T, GppNHp | | 分子名称: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.587 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
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4IDQ
 | | human atlastin-1 1-446, N440T, GDPAlF4- | | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, ... | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
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4IDO
 | | human atlastin-1 1-446, C-his6, GDPAlF4- | | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
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4IDN
 | | Human atlastin-1 1-446, C-his6, GppNHp | | 分子名称: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
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3GB1
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2W4C
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2W4D
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2VH7
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2LEN
 | | Solution structure of UCHL1 S18Y variant | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | 著者 | Tse, H. | | 登録日 | 2011-06-19 | | 公開日 | 2012-06-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1
to be published
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6ZE8
 | | Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01 | | 分子名称: | 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine, Chitotriosidase-1, GLYCEROL, ... | | 著者 | Nowotny, M, Bartlomiejczak, A, Napiorkowska-Gromadzka, A. | | 登録日 | 2020-06-16 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of OATD-01 , a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
J.Med.Chem., 63, 2020
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8R42
 | | Structure of CHI3L1 in complex with inhibititor 2 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[(2~{R})-2-[(4-chlorophenyl)methyl]pyrrolidin-1-yl]piperidin-1-yl]pyridine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-10 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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8R41
 | | Structure of CHI3L1 in complex with inhibitor 1 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-10 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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8R4X
 | | Structure of Chitinase-3-like protein 1 in complex with inhibitor 30 | | 分子名称: | (2~{S},5~{S})-4-[1-(4-chloranylpyridin-2-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]-2-methyl-morpholine, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-14 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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8AUP
 | | Structure of hARG1 with a novel inhibitor. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, ... | | 著者 | Napiorkowska-Gromadzka, A, Nowak, E, Nowotny, M. | | 登録日 | 2022-08-25 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy.
Mol.Cancer Ther., 22, 2023
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6GMU
 | | Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ben-David, M, Sussman, J.L, Tawfik, D.S. | | 登録日 | 2018-05-28 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.
Mol.Biol.Evol., 37, 2020
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6G82
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6H0A
 | | Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, CALCIUM ION, ... | | 著者 | Ben-David, M, Sussman, J.L, Tawfik, D.S. | | 登録日 | 2018-07-07 | | 公開日 | 2019-07-17 | | 最終更新日 | 2020-04-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.
Mol.Biol.Evol., 37, 2020
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2XS4
 | | Structure of karilysin catalytic MMP domain in complex with magnesium | | 分子名称: | CHLORIDE ION, KARILYSIN PROTEASE, MAGNESIUM ION, ... | | 著者 | Cerda-Costa, N, Guevara, T, Karim, A.Y, Ksiazek, M, Nguyen, K.-A, Arolas, J.L, Potempa, J, Gomis-Ruth, F.X. | | 登録日 | 2010-09-24 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
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2XS3
 | | Structure of karilysin catalytic MMP domain | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, KARILYSIN PROTEASE, PEPTIDE ALA-PHE-THR-SER, ... | | 著者 | Cerda-Costa, N, Guevara, T, Karim, A.Y, Ksiazek, M, Nguyen, K.-A, Arolas, J.L, Potempa, J, Gomis-Ruth, F.X. | | 登録日 | 2010-09-24 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
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4Q1U
 | | Serum paraoxonase-1 by directed evolution with the K192Q mutation | | 分子名称: | BROMIDE ION, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ben-David, M, Sussman, J.L, Tawfik, D.S. | | 登録日 | 2014-04-04 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Catalytic stimulation by restrained active-site floppiness-the case of high density lipoprotein-bound serum paraoxonase-1.
J.Mol.Biol., 427, 2015
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