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1JN3
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FIDELITY PROPERTIES AND STRUCTURE OF M282L MUTATOR MUTANT OF DNA POLYMERASE: SUBTLE STRUCTURAL CHANGES INFLUENCE THE MECHANISM OF NUCLEOTIDE DISCRIMINATION
分子名称: DNA POLYMERASE BETA
著者Conn, D.A, Sweasy, J.B, Jaeger, J.
登録日2001-07-22
公開日2001-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability
Biochemistry, 40, 2001
4PPX
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DNA Polymerase Beta E295K with Spiroiminodihydantoin in Templating Position
分子名称: 5'-D(*CP*CP*GP*AP*CP*(SDH)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*G)-3', ...
著者Eckenroth, B.E, Doublie, S.
登録日2014-02-27
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Crystal Structure of DNA Polymerase beta with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position.
Biochemistry, 53, 2014
6UOL
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Y271G DNA polymerase beta substrate complex with a templating cytosine and incoming rGTP
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Smith, M.R, Freudenthal, B.D.
登録日2019-10-15
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.936 Å)
主引用文献Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
6UOK
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Y271G DNA polymerase beta substrate complex with templating cytosine and incoming r8-oxo-GTP
分子名称: 1,2-ETHANEDIOL, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
著者Smith, M.R, Freudenthal, B.D.
登録日2019-10-15
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
6UOM
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Y271G DNA polymerase beta ternary complex with templating adenine and incoming r8-oxo-GTP
分子名称: 1,2-ETHANEDIOL, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, ...
著者Smith, M.R, Freudenthal, B.D.
登録日2019-10-15
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
3UXO
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Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme
分子名称: DNA polymerase beta
著者Gridley, C.L, Jaeger, J.
登録日2011-12-05
公開日2012-12-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3UXP
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Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP
分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', ...
著者Gridley, C.L, Jaeger, J.
登録日2011-12-05
公開日2012-12-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.723 Å)
主引用文献Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3V7J
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Co-crystal structure of Wild Type Rat polymerase beta: Enzyme-DNA binary complex
分子名称: CHLORIDE ION, DNA (5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*AP*AP*CP*TP*CP*AP*CP*AP*TP*A)-3'), ...
著者Rangarajan, S, Jaeger, J.
登録日2011-12-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3V7K
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Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex
分子名称: DNA (5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*AP*AP*CP*TP*CP*AP*CP*AP*A)-3'), DNA polymerase beta, ...
著者Rangarajan, S, Jaeger, J.
登録日2011-12-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.271 Å)
主引用文献Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3V7L
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Apo Structure of Rat DNA polymerase beta K72E variant
分子名称: CHLORIDE ION, DNA polymerase beta, SODIUM ION, ...
著者Rangarajan, S, Jaeger, J.
登録日2011-12-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3UXN
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BU of 3uxn by Molmil
Crystal Structure of Rat DNA Polymerase Beta, Wild Type Apoenzyme
分子名称: DNA polymerase beta
著者Gridley, C.L, Firbank, S, Jaeger, J.
登録日2011-12-05
公開日2012-12-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3V72
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Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA
分子名称: CHLORIDE ION, DNA 5'-D(P*AP*AP*AP*CP*TP*CP*AP*CP*AP*T)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3', ...
著者Gridley, C.L, Jaeger, J.
登録日2011-12-20
公開日2012-07-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway
J.Am.Chem.Soc., 134, 2012
5U8G
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DNA Polymerase Beta crystallized in PEG 400
分子名称: CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
著者Eckenroth, B.E, Doublie, S.
登録日2016-12-14
公開日2017-04-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.166 Å)
主引用文献Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
5U8I
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DNA Polymerase Beta S229L crystallized in PEG 400
分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
著者Eckenroth, B.E, Doublie, S.
登録日2016-12-14
公開日2017-04-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
5U8H
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DNA Polymerase Beta G231D crystallized in PEG 400
分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
著者Eckenroth, B.E, Doublie, S.
登録日2016-12-14
公開日2017-04-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.155 Å)
主引用文献Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
6BTF
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DNA Polymerase Beta I260Q Ternary Complex
分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
著者Eckenroth, B.E, Doublie, S.
登録日2017-12-06
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
6BTE
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BU of 6bte by Molmil
DNA Polymerase Beta I260Q Binary Complex
分子名称: CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ...
著者Eckenroth, B.E, Doublie, S.
登録日2017-12-06
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
6NKZ
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma methylene dGTP
分子名称: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*TP*(2DT))-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKX
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKT
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma difluoro analogue of dGTP
分子名称: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKY
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP
分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.094 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKV
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Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP
分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKR
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKU
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BU of 6nku by Molmil
Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKS
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Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP
分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Batra, V.K, Wilson, S.H.
登録日2019-01-07
公開日2020-01-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020

 

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