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7XFA
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BU of 7xfa by Molmil
Structure of human Galectin-3 CRD in complex with monosaccharide inhibitor
分子名称: (2~{S},3~{R},4~{R},5~{R},6~{R})-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-[2-[5-chloranyl-2-(trifluoromethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,5-diol, Galectin-3
著者Shukla, J, Raman, S, Ghosh, K.
登録日2022-04-01
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
J.Med.Chem., 65, 2022
4NQW
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BU of 4nqw by Molmil
Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA
分子名称: Anti-sigma-K factor RskA, CADMIUM ION, ECF RNA polymerase sigma factor SigK
著者Shukla, J.K, Gopal, B.
登録日2013-11-25
公開日2014-01-22
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA sigma-anti-sigma complex
Acta Crystallogr.,Sect.D, 70, 2014
8ABY
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BU of 8aby by Molmil
RNA polymerase bound to purified in vitro transcribed regulatory RNA putL - pause prone, closed clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-05
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8AC0
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BU of 8ac0 by Molmil
RNA polymerase at U-rich pause bound to regulatory RNA putL - active, closed clamp state
分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ...
著者Weixlbaumer, A, Dey, S.
登録日2022-07-05
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8AD1
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BU of 8ad1 by Molmil
RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-07
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8ACP
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BU of 8acp by Molmil
RNA polymerase at U-rich pause bound to regulatory RNA putL - inactive, open clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-06
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8ABZ
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BU of 8abz by Molmil
RNA polymerase at U-rich pause bound to non-regulatory RNA - pause prone, closed clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-05
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8AC2
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BU of 8ac2 by Molmil
RNA polymerase- post-terminated, open clamp state
分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-05
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8AC1
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BU of 8ac1 by Molmil
RNA polymerase at U-rich pause bound to non-regulatory RNA - inactive, open clamp state
分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-05
公開日2022-10-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.06 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8ILU
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BU of 8ilu by Molmil
Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor
分子名称: (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, SODIUM ION, ...
著者Kumar, A, Jinal, S, Raman, S, Ghosh, K.
登録日2023-03-04
公開日2024-03-06
最終更新日2024-09-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.
Bioorg.Med.Chem., 101, 2024

226707

件を2024-10-30に公開中

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