5W4K
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![BU of 5w4k by Molmil](/molmil-images/mine/5w4k) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Metelev, M, Osterman, I.A, Ghilarov, D, Khabibullina, N.F, Yakimov, A, Shabalin, K, Utkina, I, Travin, D.Y, Komarova, E.S, Serebryakova, M, Artamonova, T, Khodorkovskii, M, Konevega, A.L, Sergiev, P.V, Severinov, K, Polikanov, Y.S. | 登録日 | 2017-06-12 | 公開日 | 2017-08-30 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat. Chem. Biol., 13, 2017
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5K99
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![BU of 5k99 by Molmil](/molmil-images/mine/5k99) | Crystal structure of microcin immunity protein MccF from Bacillus anthracis in complex with McC | 分子名称: | ADENOSINE MONOPHOSPHATE, Microcin C, Microcin C7 self-immunity protein mccF | 著者 | Nocek, B, Kulikovsky, A, Severinov, K, Dubiley, S, Joachimiak, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-05-31 | 公開日 | 2017-03-22 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of microcin immunity protein MccF from Bacillus anthracis in complex with McC To Be Published
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6U48
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![BU of 6u48 by Molmil](/molmil-images/mine/6u48) | E. coli 50S with phazolicin (PHZ) bound in exit tunnel | 分子名称: | 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ... | 著者 | Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K. | 登録日 | 2019-08-23 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition. Nat Commun, 10, 2019
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1HQM
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![BU of 1hqm by Molmil](/molmil-images/mine/1hqm) | CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Minakhin, L, Bhagat, S, Brunning, A, Campbell, E.A, Darst, S.A, Ebright, R.H, Severinov, K. | 登録日 | 2000-12-18 | 公開日 | 2001-02-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly. Proc.Natl.Acad.Sci.USA, 98, 2001
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4ZJN
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![BU of 4zjn by Molmil](/molmil-images/mine/4zjn) | Crystal structure of the bacteriophage G20C portal protein | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Portal protein | 著者 | Williams, L.S, Turkenburg, J.P, Levdikov, V.M, Minakhin, L, Severinov, K, Antson, A.A. | 登録日 | 2015-04-29 | 公開日 | 2015-05-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Crystal structure of the bacteriophage G20C portal protein To be published
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2WNM
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![BU of 2wnm by Molmil](/molmil-images/mine/2wnm) | Solution structure of Gp2 | 分子名称: | GENE 2 | 著者 | Camara, B, Liu, M, Shadrinc, A, Liu, B, Simpson, P, Weinzierl, R, Severinovc, K, Cota, E, Matthews, S, Wigneshweraraj, S.R. | 登録日 | 2009-07-13 | 公開日 | 2010-02-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site. Proc.Natl.Acad.Sci.USA, 107, 2010
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5UI7
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![BU of 5ui7 by Molmil](/molmil-images/mine/5ui7) | Solution NMR Structure of Lasso Peptide Klebsidin | 分子名称: | Klebsidin | 著者 | Bushin, L.B, Metelev, M, Severinov, K, Seyedsayamdost, M.R. | 登録日 | 2017-01-13 | 公開日 | 2017-02-08 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae. ACS Chem. Biol., 12, 2017
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5UI6
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![BU of 5ui6 by Molmil](/molmil-images/mine/5ui6) | Solution NMR Structure of Lasso Peptide Acinetodin | 分子名称: | Acinetodin | 著者 | Bushin, L.B, Metelev, M, Severinov, K, Seyedsayamdost, M.R. | 登録日 | 2017-01-12 | 公開日 | 2017-02-08 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae. ACS Chem. Biol., 12, 2017
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5XJ0
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![BU of 5xj0 by Molmil](/molmil-images/mine/5xj0) | T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. | 登録日 | 2017-04-28 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (4.004 Å) | 主引用文献 | A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
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4E94
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![BU of 4e94 by Molmil](/molmil-images/mine/4e94) | Crystal structure of MccF-like protein from Streptococcus pneumoniae | 分子名称: | GLYCEROL, MccC family protein, SULFATE ION | 著者 | Nocek, B, Tikhonov, A, Kwon, K, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-03-20 | 公開日 | 2012-05-09 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Crystal structure of MccF-like protein from Streptococcus pneumoniae TO BE PUBLISHED
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4MI1
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![BU of 4mi1 by Molmil](/molmil-images/mine/4mi1) | Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with aspartyl sulfamoyl adenylates | 分子名称: | 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, Microcin immunity protein MccF, SULFATE ION | 著者 | Nocek, B, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-08-30 | 公開日 | 2014-04-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with aspartyl sulfamoyl adenylates TO BE PUBLISHED
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1YNN
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![BU of 1ynn by Molmil](/molmil-images/mine/1ynn) | Taq RNA polymerase-rifampicin complex | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Campbell, E.A, Pavlova, O, Zenkin, N, Leon, F, Irschik, H, Jansen, R, Severinov, K, Darst, S.A. | 登録日 | 2005-01-24 | 公開日 | 2005-03-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase Embo J., 24, 2005
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2MC5
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![BU of 2mc5 by Molmil](/molmil-images/mine/2mc5) | A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement | 分子名称: | 45L | 著者 | Liu, B, Shadrin, A, Sheppard, C, Xu, Y, Severinov, K, Matthews, S, Wigneshweraraj, S. | 登録日 | 2013-08-14 | 公開日 | 2014-03-26 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement. Nucleic Acids Res., 42, 2014
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2MC6
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![BU of 2mc6 by Molmil](/molmil-images/mine/2mc6) | A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement | 分子名称: | DNA-directed RNA polymerase subunit beta', RNA polymerase inhibitor p7 | 著者 | Liu, B, Shadrin, A, Sheppard, C, Xu, Y, Severinov, K, Matthews, S, Wigneshweraraj, S. | 登録日 | 2013-08-15 | 公開日 | 2014-04-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement. Nucleic Acids Res., 42, 2014
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2MW3
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![BU of 2mw3 by Molmil](/molmil-images/mine/2mw3) | Solution NMR structure of the lasso peptide streptomonomicin | 分子名称: | Lasso peptide | 著者 | Tietz, J.I, Zhu, L, Mitchell, D.A, Metelev, M, Melby, J.O, Blair, P.M, Livnat, I, Severinov, K. | 登録日 | 2014-10-24 | 公開日 | 2015-01-28 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. Chem.Biol., 22, 2015
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6GRG
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![BU of 6grg by Molmil](/molmil-images/mine/6grg) | E. coli Microcin synthetase McbBCD complex with pro-MccB17, ADP and phosphate bound | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | 登録日 | 2018-06-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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6GRI
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![BU of 6gri by Molmil](/molmil-images/mine/6gri) | E. coli Microcin synthetase McbBCD complex | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, Microcin B17-processing protein McbB, ... | 著者 | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | 登録日 | 2018-06-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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6GRH
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![BU of 6grh by Molmil](/molmil-images/mine/6grh) | E. coli Microcin synthetase McbBCD complex with truncated pro-MccB17 bound | 分子名称: | 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ... | 著者 | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | 登録日 | 2018-06-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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6GOS
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![BU of 6gos by Molmil](/molmil-images/mine/6gos) | E. coli Microcin synthetase McbBCD complex with pro-MccB17 bound | 分子名称: | 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ... | 著者 | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | 登録日 | 2018-06-04 | 公開日 | 2019-01-30 | 最終更新日 | 2019-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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3WOF
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![BU of 3wof by Molmil](/molmil-images/mine/3wof) | Crystal structure of P23-45 gp39 (6-132) bound to Thermus thermophilus RNA polymerase beta-flap domain | 分子名称: | DNA-directed RNA polymerase subunit beta, Putative uncharacterized protein | 著者 | Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. | 登録日 | 2013-12-26 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.298 Å) | 主引用文献 | Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
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3WOE
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![BU of 3woe by Molmil](/molmil-images/mine/3woe) | Crystal structure of P23-45 gp39 (6-109) bound to Thermus thermophilus RNA polymerase beta-flap domain | 分子名称: | DNA-directed RNA polymerase subunit beta, Putative uncharacterized protein | 著者 | Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. | 登録日 | 2013-12-26 | 公開日 | 2014-03-12 | 最終更新日 | 2015-03-25 | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | 主引用文献 | Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
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3WOD
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![BU of 3wod by Molmil](/molmil-images/mine/3wod) | RNA polymerase-gp39 complex | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. | 登録日 | 2013-12-26 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
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4INJ
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![BU of 4inj by Molmil](/molmil-images/mine/4inj) | Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Lmo1638 protein, ... | 著者 | Nocek, B, Tikhonov, A, Severinov, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-01-04 | 公開日 | 2013-02-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product To be Published
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4JVO
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![BU of 4jvo by Molmil](/molmil-images/mine/4jvo) | Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with alanyl sulfamoyl adenylates | 分子名称: | '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, GLYCEROL, Microcin immunity protein MccF | 著者 | Nocek, B, Tikhonov, A, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-03-25 | 公開日 | 2013-06-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with alanyl sulfamoyl adenylates TO BE PUBLISHED
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5F5X
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![BU of 5f5x by Molmil](/molmil-images/mine/5f5x) | |