7TJ5
| SthK closed state, cAMP-bound in the presence of POPA | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | 著者 | Schmidpeter, P.A, Nimigean, C.M. | 登録日 | 2022-01-14 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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7TJ6
| SthK open state, cAMP-bound in the presence of POPA | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | 著者 | Schmidpeter, P.A, Nimigean, C.M. | 登録日 | 2022-01-14 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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6VXZ
| SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M. | 登録日 | 2020-02-25 | 公開日 | 2020-11-11 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel. Nat Commun, 11, 2020
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6VY0
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8DE7
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent | 分子名称: | DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE9
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE8
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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7TKT
| SthK closed state, cAMP-bound in the presence of detergent | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | 著者 | Rheinberger, J, Schmidpeter, P.A, Nimigean, C.M. | 登録日 | 2022-01-17 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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8VTA
| SthK R120A in the presence of PIP2 and cAMP | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | 登録日 | 2024-01-26 | 公開日 | 2024-09-25 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK. Nat Commun, 15, 2024
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8VT9
| WT SthK in the presence of PIP2 and cAMP | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | 登録日 | 2024-01-26 | 公開日 | 2024-09-25 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK. Nat Commun, 15, 2024
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8VTB
| SthK R120A R124A in the presence of PIP2 and cAMP | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | 登録日 | 2024-01-26 | 公開日 | 2024-09-25 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK. Nat Commun, 15, 2024
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3ZHH
| X-ray structure of the full-length beta-lactamase from M.tuberculosis | 分子名称: | BETA-LACTAMASE, SULFATE ION | 著者 | Feiler, C, Fisher, A.C, Marrichi, M.J, Wright, L, Schmidpeter, P.A.M, Blankenfeldt, W, Pavelka, M, DeLisa, M.P. | 登録日 | 2012-12-21 | 公開日 | 2013-09-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Directed Evolution of Mycobacterium Tuberculosis Beta-Lactamase Reveals Gatekeeper Residue that Regulates Antibiotic Resistance and Catalytic Efficiency. Plos One, 8, 2013
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4WO7
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5IUX
| GLIC-V135C bimane labelled X-ray structure | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, ACETATE ION, ... | 著者 | Fourati, Z, Menny, A, Delarue, M. | 登録日 | 2016-03-18 | 公開日 | 2017-03-29 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification of a pre-active conformation of a pentameric channel receptor. Elife, 6, 2017
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5EX2
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5EX1
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6CJT
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6CJU
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6CJQ
| Structure of the SthK cyclic nucleotide-gated potassium channel | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | 著者 | Nimigean, C.M, Rheinberger, J. | 登録日 | 2018-02-26 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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7RYS
| SthK R120A Open State 2 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C, Schmidpeter, P. | 登録日 | 2021-08-26 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RU0
| SthK R120A Open State 1 | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C, Schmidpeter, P. | 登録日 | 2021-08-16 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RYR
| SthK R120A Open State 3 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C, Schmidpeter, P. | 登録日 | 2021-08-26 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RSH
| SthK Y26F Closed State | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C. | 登録日 | 2021-08-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RTF
| SthK R120A Closed State | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C. | 登録日 | 2021-08-13 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RTJ
| SthK Y26F Activated State | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | 著者 | Gao, X, Nimigean, C. | 登録日 | 2021-08-13 | 公開日 | 2022-11-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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