3ZM9
| The mechanism of allosteric coupling in choline kinase a1 revealed by a rationally designed inhibitor | 分子名称: | 1-(4-(4-(4-((6-amino-9H-purin-9-yl)methyl)phenyl)butyl)benzyl)-4- (dimethylamino)pyridinium, CHOLINE KINASE ALPHA | 著者 | Sahun-Roncero, M, Rubio-Ruiz, B, Saladino, G, Conejo-Garcia, A, Espinosa, A, Velazquez-Campoy, A, Gervasio, F.L, Entrena, A, Hurtado-Guerrero, R. | 登録日 | 2013-02-06 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Mechanism of Allosteric Coupling in Choline Kinase A1 Revealed by a Rationally Designed Inhibitor Angew.Chem.Int.Ed.Engl., 52, 2013
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5LVO
| Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket | 分子名称: | 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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5LVM
| Human PDK1 Kinase Domain in Complex with Adenine Bound to the ATP-Binding Site | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, ADENINE, DITHIANE DIOL | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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5LVL
| Human PDK1 Kinase Domain in Complex with Compound PS653 Bound to the ATP-Binding Site | 分子名称: | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 3-phosphoinositide-dependent protein kinase 1, DIMETHYL SULFOXIDE, ... | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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5LVN
| Human PDK1 Kinase Domain in Complex with Adenosine Bound to the ATP-Binding Site | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, ADENOSINE, CHLORIDE ION, ... | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.379 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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5LVP
| Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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8SGD
| Crystal Structure of CDC3(G) - CDC10(Delta 1-10) heterocomplex from Saccharomyces cerevisiae | 分子名称: | CDC10 isoform 1, CDC3 isoform 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Saladino, G.C.R, Leonardo, D.A, Pereira, H.M, Garratt, R.C. | 登録日 | 2023-04-12 | 公開日 | 2023-06-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly. J.Struct.Biol., 215, 2023
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8FWP
| Crystal Structure of CDC10 - CDC3 heterocomplex from Saccharomyces cerevisiae | 分子名称: | Cell division control protein 10, Cell division control protein 3, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Silva, R.M, Leonardo, D.A, Pereira, H.M, Garratt, R.C. | 登録日 | 2023-01-23 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly. J.Struct.Biol., 215, 2023
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4J23
| Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex | 分子名称: | Fibroblast growth factor 1, Fibroblast growth factor receptor 2 | 著者 | Kudlinzki, D, Saxena, K, Sreeramulu, S, Schieborr, U, Dreyer, M, Schreuder, H, Schwalbe, H. | 登録日 | 2013-02-04 | 公開日 | 2014-02-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.882 Å) | 主引用文献 | Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell, 23, 2013
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