7SZQ
 
 | | Human P300 complexed with an azaindazole inhibitor | | 分子名称: | 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide, Histone acetyltransferase p300 | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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7SSK
 | | Human P300 complexed with a glycine-based inhibitor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Histone acetyltransferase p300, ... | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-11 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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7SS8
 | | Human P300 complexed with a proline-based inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-{[3-(methylcarbamoyl)phenyl]methyl}-D-prolinamide, Histone acetyltransferase p300, ... | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-10 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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4Z2A
 | | Crystal structure of unglycosylated apo human furin @1.89A | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Furin, ... | | 著者 | Gampe, R.T, Pearce, K, Reid, R. | | 登録日 | 2015-03-29 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | BacMam production and crystal structure of nonglycosylated apo human furin at 1.89A resolution
Acta Crystallogr.,Sect.F, 2019
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3C9W
 | | Crystal Structure of ERK-2 with hypothemycin covalently bound | | 分子名称: | (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione, Mitogen-activated protein kinase 1 | | 著者 | Rosenfeld, R.J. | | 登録日 | 2008-02-18 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular modeling and crystal structure of ERK2-hypothemycin complexes
J.Struct.Biol., 164, 2008
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6Z9V
 | | Human Class I Major Histocompatibility Complex, A02 allele, presenting IIGWMWIPV | | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... | | 著者 | Rizkallah, P.J, Man, S, Redman, J.E. | | 登録日 | 2020-06-04 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.
J Immunol., 207, 2021
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6Z9X
 | | Human Class I Major Histocompatibility Complex, A02 allele, presenting LLS (t-butyl)Y FGTPT | | 分子名称: | Beta-2-microglobulin, LEU-LEU-SER-TUR-PHE-GLY-THR-PRO-THR, MHC class I antigen, ... | | 著者 | Rizkallah, P.J, Man, S, Redman, J.E. | | 登録日 | 2020-06-04 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.
J Immunol., 207, 2021
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6Z9W
 | | Human Class I Major Histocompatibility Complex, A02 allele, presenting LLGWVFAQV | | 分子名称: | Beta-2-microglobulin, LEU-LEU-GLY-TRP-VAL-PHE-ALA-GLN-VAL, MHC class I antigen | | 著者 | Rizkallah, P.J, Man, S, Redman, J.E. | | 登録日 | 2020-06-04 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.
J Immunol., 207, 2021
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7LCU
 | | X-ray structure of Furin bound to BOS-318, a small molecule inhibitor | | 分子名称: | (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | | 著者 | Campobasso, N, Reid, R. | | 登録日 | 2021-01-11 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.
Cell Chem Biol, 29, 2022
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