2PZV
 
 | | Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas Putida (pksi) with bound Phenol | | 分子名称: | PHENOL, Steroid Delta-isomerase | | 著者 | Pybus, B, Caaveiro, J.M.M, Petsko, G.A, Ringe, D. | | 登録日 | 2007-05-18 | | 公開日 | 2007-06-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Testing Electrostatic complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole
PLoS Biol., 4, 2006
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3CPO
 | | Crystal structure of ketosteroid isomerase D40N with bound 2-fluorophenol | | 分子名称: | 2-fluorophenol, Delta(5)-3-ketosteroid isomerase | | 著者 | Caaveiro, J.M.M, Pybus, B, Ringe, D, Petsko, G. | | 登録日 | 2008-03-31 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole
J.Am.Chem.Soc., 130, 2008
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3VGN
 | | Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound 3-fluoro-4-nitrophenol | | 分子名称: | 3-fluoro-4-nitrophenol, Steroid Delta-isomerase | | 著者 | Caaveiro, J.M.M, Pybus, B, Ringe, D, Petsko, G.A, Sigala, P.A. | | 登録日 | 2011-08-16 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site
Proc.Natl.Acad.Sci.USA, 110, 2013
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2INX
 | | Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound 2,6-difluorophenol | | 分子名称: | 2,6-DIFLUOROPHENOL, Steroid delta-isomerase | | 著者 | Martinez Caaveiro, J.M, Pybus, B, Ringe, D, Petsko, G.A, Sigala, P, Kraut, D, Herschlag, D. | | 登録日 | 2006-10-09 | | 公開日 | 2007-10-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole.
J.Am.Chem.Soc., 130, 2008
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3FZW
 | | Crystal Structure of Ketosteroid Isomerase D40N-D103N from Pseudomonas putida (pKSI) with bound equilenin | | 分子名称: | EQUILENIN, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Caaveiro, J.M.M, Ringe, D, Petsko, G.A. | | 登録日 | 2009-01-26 | | 公開日 | 2009-06-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Hydrogen bond coupling in the ketosteroid isomerase active site.
Biochemistry, 48, 2009
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3OWS
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6TCZ
 | | Leishmania tarentolae proteasome 20S subunit complexed with LXE408 | | 分子名称: | Proteasome endopeptidase complex, Proteasome subunit alpha type, Proteasome subunit beta, ... | | 著者 | Srinivas, H. | | 登録日 | 2019-11-07 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J.Med.Chem., 63, 2020
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6TD5
 | | Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib | | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome endopeptidase complex, Proteasome subunit alpha type, ... | | 著者 | Srinivas, H. | | 登録日 | 2019-11-07 | | 公開日 | 2020-08-26 | | 最終更新日 | 2020-10-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J.Med.Chem., 63, 2020
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