8YTE
 
 | | Crystal Structure of TrkA D5 domain in complex with macrocyclic peptide | | 分子名称: | 1,2-ETHANEDIOL, AMINOMETHYLAMIDE, High affinity nerve growth factor receptor, ... | | 著者 | Yamada, T, Mihara, K, Ueda, T, Yamauchi, D, Shimizu, M, Ando, A, Mayumi, K, Nakata, Z, Mikamiyama, H. | | 登録日 | 2024-03-25 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists
J.Med.Chem., 2024
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8YTD
 | | Crystal Structure of TrkA D5 domain in complex with two different macrocyclic peptides | | 分子名称: | 1,2-ETHANEDIOL, High affinity nerve growth factor receptor, Macrocyclic Peptide | | 著者 | Yamada, T, Mihara, K, Ueda, T, Yamauchi, D, Shimizu, M, Ando, A, Mayumi, K, Nakata, Z, Mikamiyama, H. | | 登録日 | 2024-03-25 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists
J.Med.Chem., 2024
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3WSZ
 | | SorLA Vps10p domain in complex with Abeta-derived peptide | | 分子名称: | 10-mer peptide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin-related receptor | | 著者 | Kitago, Y, Nakata, Z, Nagae, M, Nogi, T, Takagi, J. | | 登録日 | 2014-03-30 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | Structural basis for amyloidogenic peptide recognition by sorLA.
Nat.Struct.Mol.Biol., 22, 2015
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3WSY
 | | SorLA Vps10p domain in complex with its own propeptide fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin-related receptor, peptide from Sortilin-related receptor | | 著者 | Kitago, Y, Nakata, Z, Nagae, M, Nogi, T, Takagi, J. | | 登録日 | 2014-03-30 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Structural basis for amyloidogenic peptide recognition by sorLA.
Nat.Struct.Mol.Biol., 22, 2015
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3WSX
 | | SorLA Vps10p domain in ligand-free form | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ... | | 著者 | Kitago, Y, Nakata, Z, Nagae, M, Nogi, T, Takagi, J. | | 登録日 | 2014-03-30 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis for amyloidogenic peptide recognition by sorLA.
Nat.Struct.Mol.Biol., 22, 2015
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7YF6
 | | Crystal structure of HIV-1 protease in complex with macrocyclic peptide | | 分子名称: | MAGNESIUM ION, Macrocyclic Peptide, Protease | | 著者 | Kusumoto, Y, Sato, S, Yamada, T, Kozono, I, Nakata, Z, Asada, N, Mitsuki, S, Wakasa-Morimoto, C, Tohru, M, Watanabe, A, Hayashi, K, Mikamiyama, H. | | 登録日 | 2022-07-07 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization.
Acs Med.Chem.Lett., 13, 2022
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7WCQ
 | | Crystal structure of HIV-1 protease in complex with lactam derivative 1 | | 分子名称: | (3R,4R)-3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-3-(4-methylsulfonylphenyl)-4-oxidanyl-pyrrolidin-2-one, Protease | | 著者 | Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakasa-Morimoto, C, Tachibana, Y, Fumoto, M. | | 登録日 | 2021-12-20 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | | 主引用文献 | Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.
J.Med.Chem., 65, 2022
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7WBS
 | | Crystal structure of HIV-1 protease in complex with lactam derivative 2 | | 分子名称: | (3~{R},4~{R})-1-[(4-methoxyphenyl)methyl]-3-(3-methylbutyl)-3-[4-methylsulfonyl-2-[(2~{S})-1-oxidanylpropan-2-yl]oxy-phenyl]-4-oxidanyl-pyrrolidin-2-one, GLYCEROL, Protease | | 著者 | Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakabayashi-Morimoto, C, Tachibana, Y, Fumoto, M. | | 登録日 | 2021-12-17 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.
J.Med.Chem., 65, 2022
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