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8BBF
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BU of 8bbf by Molmil
Structure of the IFT-A complex; IFT-A1 module
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, WD repeat-containing protein 19
著者Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J.
登録日2022-10-12
公開日2022-12-07
最終更新日2023-01-04
実験手法ELECTRON MICROSCOPY (8 Å)
主引用文献IFT-A structure reveals carriages for membrane protein transport into cilia.
Cell, 185, 2022
8BBE
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BU of 8bbe by Molmil
Structure of the IFT-A complex; IFT-A2 module
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, SNAP-tag,Tetratricopeptide repeat protein 21B, ...
著者Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J.
登録日2022-10-12
公開日2022-12-21
最終更新日2023-01-04
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献IFT-A structure reveals carriages for membrane protein transport into cilia.
Cell, 185, 2022
8BBG
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BU of 8bbg by Molmil
Structure of the IFT-A complex; anterograde IFT-A train model
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ...
著者Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J.
登録日2022-10-12
公開日2022-12-21
最終更新日2023-01-04
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献IFT-A structure reveals carriages for membrane protein transport into cilia.
Cell, 185, 2022
3QI1
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BU of 3qi1 by Molmil
Design and synthesis of hydroxyethylamine (hea) BACE-1 inhibitors: prime side chromane-containing inhibitors
分子名称: Beta-secretase 1, N-[(2S,3R)-4-{[(2R,4S)-2-cyclopropyl-6-(2,2-dimethylpropyl)-3,4-dihydro-2H-chromen-4-yl]amino}-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
著者Yao, N.
登録日2011-01-26
公開日2012-03-28
最終更新日2013-12-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
7FHT
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BU of 7fht by Molmil
Crystal structure of DYRK1A in complex with RD0448
分子名称: (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者Kikuchi, M, Sumida, Y, Hosoya, T, Kii, I, Umehara, T.
登録日2021-07-30
公開日2022-03-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
7FHS
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BU of 7fhs by Molmil
Crystal structure of DYRK1A in complex with RD0392
分子名称: (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL
著者Kikuchi, M, Sumida, T, Hosoya, T, Kii, I, Umehara, T.
登録日2021-07-30
公開日2022-03-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022

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件を2024-06-12に公開中

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