3VN9
 
 | | Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state | | 分子名称: | 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine, Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION | | 著者 | Kinoshita, T, Matsuzaka, H, Nakai, R, Kirii, Y, Yokota, K, Tada, T, Matsumoto, T. | | 登録日 | 2012-01-05 | | 公開日 | 2012-02-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state
J.Biochem., 151, 2012
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5ETY
 | | Crystal Structure of human Tankyrase-1 bound to K-756 | | 分子名称: | 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one, Tankyrase-1, ZINC ION | | 著者 | Takahashi, Y, Miyagi, H, Suzuki, M, Saito, J. | | 登録日 | 2015-11-18 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase
Mol.Cancer Ther., 15, 2016
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3A4O
 | | Lyn kinase domain | | 分子名称: | STAUROSPORINE, Tyrosine-protein kinase Lyn | | 著者 | Miyano, N, Kinoshita, T, Tada, T. | | 登録日 | 2009-07-11 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for the inhibitor recognition of human Lyn kinase domain
Bioorg.Med.Chem.Lett., 19, 2009
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7CE4
 | | Tankyrase2 catalytic domain in complex with K-476 | | 分子名称: | 5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | | 著者 | Takahashi, Y, Suzuki, M, Saito, J. | | 登録日 | 2020-06-22 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors.
Am J Cancer Res, 11, 2021
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3VUH
 | | Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1 | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ... | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-06-28 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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3VUL
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3VUK
 | | Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1 | | 分子名称: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-07-02 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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3VUI
 | | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | | 分子名称: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-06-28 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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3VUG
 | | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | | 分子名称: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-06-28 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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3VUD
 | | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | | 分子名称: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-06-28 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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3VUM
 | | Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ... | | 著者 | Nakaniwa, T, Kinoshita, T, Inoue, T. | | 登録日 | 2012-07-02 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
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