2WAJ
| Crystal structure of human Jnk3 complexed with a 1-aryl-3,4- dihydroisoquinoline inhibitor | 分子名称: | 1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE, MITOGEN-ACTIVATED PROTEIN KINASE 10 | 著者 | Bax, B.D, Christopher, J.A, Jones, E.J, Mosley, J.E. | 登録日 | 2009-02-08 | 公開日 | 2009-03-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 1-Aryl-3,4-Dihydroisoquinoline Inhibitors of Jnk3. Bioorg.Med.Chem.Lett., 19, 2009
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6HHO
| Crystal structure of RIP1 kinase in complex with GSK547 | 分子名称: | 6-[4-[(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Thorpe, J.H, Harris, P.A. | 登録日 | 2018-08-28 | 公開日 | 2018-12-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell, 34, 2018
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6R5F
| Crystal structure of RIP1 kinase in complex with DHP77 | 分子名称: | Receptor-interacting serine/threonine-protein kinase 1, [(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | 著者 | Thorpe, J.H, Campobasso, N, Harris, P.A. | 登録日 | 2019-03-25 | 公開日 | 2019-05-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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6OCQ
| Crystal structure of RIP1 kinase in complex with a pyrrolidine | 分子名称: | 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION | 著者 | Thorpe, J.H, Harris, P.A. | 登録日 | 2019-03-25 | 公開日 | 2019-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.793 Å) | 主引用文献 | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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5MGZ
| Streptomyces Spheroides NovO (8-demethylnovbiocic acid methyltransferase) with SAH | 分子名称: | 8-demethylnovobiocic acid C(8)-methyltransferase, ACETATE ION, GLYCEROL, ... | 著者 | Chung, C.-W, Mosley, J, Sadler, J.C. | 登録日 | 2016-11-22 | 公開日 | 2017-01-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO. ACS Chem. Biol., 12, 2017
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