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5TDQ
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BU of 5tdq by Molmil
Crystal Structure of the GOLD domain of ACBD3
分子名称: Golgi resident protein GCP60
著者McPhail, J.A, Burke, J.E.
登録日2016-09-19
公開日2016-11-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase III beta , PI4KB, through ACBD3.
Structure, 25, 2017
6OAC
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BU of 6oac by Molmil
PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha
分子名称: 4-(difluoromethyl)-5-{4-[(3S)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Burke, J.E, McPhail, J.A.
登録日2019-03-15
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
J.Med.Chem., 62, 2019
7R9V
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BU of 7r9v by Molmil
Structure of PIK3CA with covalent inhibitor 19
分子名称: N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Burke, J.E, McPhail, J.A.
登録日2021-06-29
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha.
J.Am.Chem.Soc., 144, 2022
7R9Y
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BU of 7r9y by Molmil
Structure of PIK3CA with covalent inhibitor 22
分子名称: N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Burke, J.E, McPhail, J.A.
登録日2021-06-29
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha.
J.Am.Chem.Soc., 144, 2022
6DJL
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BU of 6djl by Molmil
Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A
分子名称: Ras-related protein Rab-11A, SH3 domain-binding protein 5
著者Burke, J.E, Jenkins, M.L, Boulanger, M.J.
登録日2018-05-25
公開日2018-09-26
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.10001159 Å)
主引用文献Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nat Commun, 9, 2018
5EUQ
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BU of 5euq by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11
分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.
J.Med.Chem., 59, 2016
5C46
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BU of 5c46 by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Phosphatidylinositol 4-kinase beta, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-06-17
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016
5C4G
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BU of 5c4g by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-06-18
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016

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