4FBN
 
 | | Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | | 登録日 | 2012-05-23 | | 公開日 | 2012-10-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Structure, 20, 2012
|
|
4EY0
 | | Structure of tandem SH2 domains from PLCgamma1 | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | | 登録日 | 2012-05-01 | | 公開日 | 2012-10-31 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Structure, 20, 2012
|
|
6SGK
 | |
6SGD
 | | Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24 | | 分子名称: | 4-[(6-ethenyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SODIUM ION, ... | | 著者 | Richards, M.W, Mas-Droux, C.P, Bayliss, R. | | 登録日 | 2019-08-04 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
|
|
6SGI
 | | Nek2 kinase bound to inhibitor 96 | | 分子名称: | 4-[(6-ethyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, Serine/threonine-protein kinase Nek2 | | 著者 | Richards, M.W, Mas-Droux, C.P, Bayliss, R. | | 登録日 | 2019-08-05 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
|
|
6SGH
 | |
