1WVQ
 
 | | Structure of conserved hypothetical protein PAE2307 from Pyrobaculum aerophilum | | 分子名称: | PHOSPHATE ION, hypothetical protein PAE2307 | | 著者 | Lott, J.S, Delbaere, L.T, Banfield, M.J, Sigrell-Simon, J.A, Baker, E.N. | | 登録日 | 2004-12-24 | | 公開日 | 2006-01-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.
J.Biol.Chem., 281, 2006
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1EVJ
 | | CRYSTAL STRUCTURE OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE (GFOR) DELTA1-22 S64D | | 分子名称: | GLUCOSE-FRUCTOSE OXIDOREDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Lott, J.S, Halbig, D, Baker, H.M, Hardman, M.J, Sprenger, G.A, Baker, E.N. | | 登録日 | 2000-04-20 | | 公開日 | 2000-12-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
J.Mol.Biol., 304, 2000
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2GL0
 | | Structure of PAE2307 in complex with adenosine | | 分子名称: | ADENOSINE, PHOSPHATE ION, conserved hypothetical protein | | 著者 | Lott, J.S, Paget, B, Johnston, J.M, Baker, E.N. | | 登録日 | 2006-04-04 | | 公開日 | 2006-06-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases.
J.Biol.Chem., 281, 2006
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4NF7
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1Y5H
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4A5Q
 | | Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex | | 分子名称: | CHI1 | | 著者 | Busby, J.N, Landsberg, M.J, Simpson, R.M, Jones, S.A, Hankamer, B, Hurst, M.R.H, Lott, J.S. | | 登録日 | 2011-10-27 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (17 Å) | | 主引用文献 | Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal Abc Toxin Complex of Yersinia Entomophaga.
J.Mol.Biol., 415, 2012
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4W1U
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4X58
 | | Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ... | | 著者 | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | | 登録日 | 2014-12-04 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
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4X59
 | | Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | | 著者 | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | | 登録日 | 2014-12-04 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
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1XKF
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1XVW
 | | Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin | | 分子名称: | Hypothetical protein Rv2238c/MT2298 | | 著者 | Li, S, Peterson, N.A, Kim, M.Y, Kim, C.Y, Hung, L.W, Yu, M, Lekin, T, Segelke, B.W, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2004-10-28 | | 公開日 | 2005-02-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
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1XXU
 | | Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin | | 分子名称: | Hypothetical protein Rv2238c/MT2298 | | 著者 | Li, S, Peterson, N.A, Kim, M.Y, Kim, C.Y, Hung, L.W, Yu, M, Lekin, T, Segelke, B.W, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2004-11-08 | | 公開日 | 2005-02-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
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4DWS
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4GKM
 | | Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (AnPRT; trpD) | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | | 著者 | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2012-08-13 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.6683 Å) | | 主引用文献 | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
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4GIU
 | | Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (AnPRT; trpD). | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | | 著者 | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2012-08-09 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.667 Å) | | 主引用文献 | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
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3ITE
 | | The third adenylation domain of the fungal SidN non-ribosomal peptide synthetase | | 分子名称: | CHLORIDE ION, SULFATE ION, SidN siderophore synthetase | | 著者 | Lee, T.V, Lott, J.S, Johnson, R.D, Johnson, L.J, Arcus, V.L. | | 登録日 | 2009-08-28 | | 公開日 | 2009-11-17 | | 最終更新日 | 2014-02-05 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
J.Biol.Chem., 285, 2010
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3LOG
 | | Crystal structure of MbtI from Mycobacterium tuberculosis | | 分子名称: | CARBONATE ION, GLYCEROL, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... | | 著者 | Bulloch, E.M.M, Lott, J.S, Baker, E.N, Johnston, J.M. | | 登録日 | 2010-02-03 | | 公開日 | 2011-02-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Chemmedchem, 5, 2010
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3MNL
 | | The crystal structure of KstR (Rv3574) from Mycobacterium tuberculosis H37Rv | | 分子名称: | TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY), TRIETHYLENE GLYCOL | | 著者 | Gao, C, Bunker, R.D, ten Bokum, A, Kendall, S.L, Stoker, N.G, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2010-04-21 | | 公開日 | 2011-04-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J. Biol. Chem., 291, 2016
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3TWP
 | | Crystal structure of M. tuberculosis TrpD in complex with an inhibitor | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-HYDROXYBENZOIC ACID, Anthranilate phosphoribosyltransferase, ... | | 著者 | Castell, A, Short, F.L, Lott, J.S. | | 登録日 | 2011-09-22 | | 公開日 | 2012-09-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
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3RV6
 | | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group | | 分子名称: | 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... | | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2011-05-06 | | 公開日 | 2012-05-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
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3RV7
 | | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group | | 分子名称: | 3-{[(1Z)-1-carboxy-3-methylbut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2011-05-06 | | 公開日 | 2012-05-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
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3UU1
 | | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS142) | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-3,5-dimethylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | | 著者 | Castell, A, Short, F.L, Lott, J.S. | | 登録日 | 2011-11-27 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
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3ST6
 | | Structure of a M. tuberculosis Synthase, MbtI, in Complex with an Isochorismate Analogue Inhibitor | | 分子名称: | 3-[(1-carboxyethenyl)oxy]-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2011-07-08 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
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3VEH
 | | Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT | | 分子名称: | 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Bulloch, E.M, Chi, G, Manos-Turvey, A, Johnston, J.M, Baker, E.N, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2012-01-08 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Biochemistry, 51, 2012
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3OA5
 | | The structure of chi1, a chitinase from Yersinia entomophaga | | 分子名称: | Chi1, GLYCEROL, NONAETHYLENE GLYCOL | | 著者 | Busby, J.N, Lott, J.S, Hurst, M.R.H. | | 登録日 | 2010-08-04 | | 公開日 | 2011-08-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga
J.Mol.Biol., 415, 2012
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