1BY3
 
 | | FHUA FROM E. COLI | | 分子名称: | N-OCTYL-2-HYDROXYETHYL SULFOXIDE, PROTEIN (FERRICHROME-IRON RECEPTOR PRECURSOR (FHUA)) | | 著者 | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | | 登録日 | 1998-10-22 | | 公開日 | 1999-01-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.
Cell(Cambridge,Mass.), 95, 1998
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1BY5
 | | FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME | | 分子名称: | FE (III) ION, FERRIC HYDROXAMATE UPTAKE PROTEIN, FERRICHROME, ... | | 著者 | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | | 登録日 | 1998-10-23 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.
Cell(Cambridge,Mass.), 95, 1998
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1HUX
 | | CRYSTAL STRUCTURE OF THE ACIDAMINOCOCCUS FERMENTANS (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE COMPONENT A | | 分子名称: | ACTIVATOR OF (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE, ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER | | 著者 | Locher, K.P, Hans, M, Yeh, A.P, Schmid, B, Buckel, W, Rees, D.C. | | 登録日 | 2001-01-04 | | 公開日 | 2001-03-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.
J.Mol.Biol., 307, 2001
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1L7V
 | | Bacterial ABC Transporter Involved in B12 Uptake | | 分子名称: | CYCLO-TETRAMETAVANADATE, VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC, Vitamin B12 transport ATP-binding protein btuD | | 著者 | Locher, K.P, Lee, A.T, Rees, D.C. | | 登録日 | 2002-03-18 | | 公開日 | 2002-05-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.
Science, 296, 2002
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7RTH
 | | Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | | 著者 | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | | 登録日 | 2021-08-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8RQF
 | | Cryo-EM structure of human NTCP-Bulevirtide complex | | 分子名称: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | | 著者 | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | | 登録日 | 2024-01-18 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Cryo-EM structure of human NTCP-Bulevirtide complex
To Be Published
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4FI3
 | | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | | 著者 | Korkhov, V.M, Mireku, S.A, Locher, K.P. | | 登録日 | 2012-06-07 | | 公開日 | 2012-09-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.466 Å) | | 主引用文献 | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
Nature, 490, 2012
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2QI9
 | | ABC-transporter BtuCD in complex with its periplasmic binding protein BtuF | | 分子名称: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | | 著者 | Hvorup, R.N, Goetz, B.A, Niederer, M, Hollenstein, K, Perozo, E, Locher, K.P. | | 登録日 | 2007-07-03 | | 公開日 | 2007-08-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.
Science, 317, 2007
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2HYD
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6QEX
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3CFZ
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3CG1
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1N2Z
 | | 2.0 Angstrom structure of BtuF, the vitamin B12 binding protein of E. coli | | 分子名称: | CADMIUM ION, CHLORIDE ION, CYANOCOBALAMIN, ... | | 著者 | Borths, E.L, Locher, K.P, Lee, A.T, Rees, D.C. | | 登録日 | 2002-10-24 | | 公開日 | 2002-12-18 | | 最終更新日 | 2021-08-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter
Proc.Natl.Acad.Sci.USA, 99, 2002
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7PHP
 | | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-18 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PIJ
 | | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-20 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
 | | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-18 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (8.45 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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3NU1
 | | Structure of holo form of a periplasmic heme binding protein | | 分子名称: | Hemin-binding periplasmic protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Mattle, D, Goetz, B.A, Woo, J.S, Locher, K.P. | | 登録日 | 2010-07-06 | | 公開日 | 2010-10-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.
J.Mol.Biol., 404, 2010
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3MD9
 | | Structure of apo form of a periplasmic heme binding protein | | 分子名称: | BROMIDE ION, GLYCEROL, Hemin-binding periplasmic protein hmuT, ... | | 著者 | Mattle, D, Goetz, B.A, Locher, K.P. | | 登録日 | 2010-03-30 | | 公開日 | 2010-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.
J.Mol.Biol., 404, 2010
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3RCE
 | | Bacterial oligosaccharyltransferase PglB | | 分子名称: | MAGNESIUM ION, Oligosaccharide transferase to N-glycosylate proteins, Substrate Mimic Peptide | | 著者 | Lizak, C, Gerber, S, Numao, S, Aebi, M, Locher, K.P. | | 登録日 | 2011-03-31 | | 公開日 | 2011-06-15 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | X-ray structure of a bacterial oligosaccharyltransferase.
Nature, 474, 2011
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6EZN
 | | Cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex | | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wild, R, Kowal, J, Eyring, J, Ngwa, E.M, Aebi, M, Locher, K.P. | | 登録日 | 2017-11-16 | | 公開日 | 2018-01-17 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Nat Commun, 13, 2022
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7QBG
 | | TC:CD320 in complex with nanobody TC-Nb4 | | 分子名称: | Anti-TC:CD320 nanobody TC-Nb4, CALCIUM ION, CD320 antigen, ... | | 著者 | Bloch, J.S, Locher, K.P. | | 登録日 | 2021-11-19 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBD
 | | TC:CD320 in complex with nanobody TC-Nb26 | | 分子名称: | Antitranscobalamin-nanobody TC-Nb26, CALCIUM ION, CD320 antigen, ... | | 著者 | Bloch, J.S, Locher, K.P. | | 登録日 | 2021-11-19 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (4.18 Å) | | 主引用文献 | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBE
 | | TC:CD320 in complex with nanobody TC-Nb11 | | 分子名称: | Anti-transcobalamin-2 nanobody TC-Nb11, CALCIUM ION, CD320 antigen, ... | | 著者 | Bloch, J.S, Locher, K.P. | | 登録日 | 2021-11-19 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBF
 | | TC:CD320 in complex with nanobody TC-Nb34 | | 分子名称: | 1,2-ETHANEDIOL, Anti-transcobalamin-2 nanobody TC-Nb34, CALCIUM ION, ... | | 著者 | Bloch, J.S, Locher, K.P. | | 登録日 | 2021-11-19 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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6GXC
 | | Bacterial oligosaccharyltransferase PglB in complex with an inhibitory peptide and a reactive lipid-linked oligosaccharide analog | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLY-ASP-GLN-DAB-ALA-THR-PPN-GLY, ... | | 著者 | Napiorkowska, M, Locher, K.P, Boilevin, J, Darbre, T, Reymond, J.-L. | | 登録日 | 2018-06-27 | | 公開日 | 2018-11-14 | | 実験手法 | X-RAY DIFFRACTION (3.401 Å) | | 主引用文献 | Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide.
Sci Rep, 8, 2018
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