4RIY
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![BU of 4riy by Molmil](/molmil-images/mine/4riy) | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Littlefield, P, Liu, L, Jura, N. | 登録日 | 2014-10-07 | 公開日 | 2014-12-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.981 Å) | 主引用文献 | Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. Sci.Signal., 7, 2014
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4RIW
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![BU of 4riw by Molmil](/molmil-images/mine/4riw) | |
4RIX
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![BU of 4rix by Molmil](/molmil-images/mine/4rix) | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Littlefield, P, Liu, L, Jura, N. | 登録日 | 2014-10-07 | 公開日 | 2014-12-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. Sci.Signal., 7, 2014
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6OP9
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![BU of 6op9 by Molmil](/molmil-images/mine/6op9) | HER3 pseudokinase domain bound to bosutinib | 分子名称: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Receptor tyrosine-protein kinase erbB-3 | 著者 | Littlefield, P, Agnew, C, Jura, N. | 登録日 | 2019-04-24 | 公開日 | 2019-08-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Cell Rep, 38, 2022
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2LPB
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![BU of 2lpb by Molmil](/molmil-images/mine/2lpb) | Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15 | 分子名称: | General control protein GCN4, Mediator of RNA polymerase II transcription subunit 15 | 著者 | Brzovic, P.S, Heikaus, C.C, Kisselev, L, Vernon, R, Herbig, E, Pacheco, D, Warfield, L, Littlefield, P, Baker, D, Klevit, R.E, Hahn, S. | 登録日 | 2012-02-07 | 公開日 | 2012-02-22 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex. Mol.Cell, 44, 2011
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