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8K7E
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BU of 8k7e by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7L
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BU of 8k7l by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7J
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BU of 8k7j by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-((dimethylamino)methyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-[(dimethylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7G
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BU of 8k7g by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7F
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BU of 8k7f by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7H
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BU of 8k7h by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R)-2-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol
分子名称: (2~{R},3~{S},4~{R})-2-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7D
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BU of 8k7d by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7I
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BU of 8k7i by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2-(hydroxymethyl)-5-((methylamino)methyl)pyrrolidine-3,4-diol
分子名称: (2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-5-(methylaminomethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
8K7K
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BU of 8k7k by Molmil
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)-1-methylpyrrolidine-3,4-diol
分子名称: (2~{R},3~{S},4~{R},5~{R})-2,5-bis(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C.
登録日2023-07-26
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.
Jacs Au, 4, 2024
6L1R
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BU of 6l1r by Molmil
Crystal structure of N-terminal domain of human SSRP1
分子名称: FACT complex subunit SSRP1
著者Li, H.Y, Hu, T.T, Dou, Y.S, Su, D.
登録日2019-09-30
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7984395 Å)
主引用文献Crystal structure of N-terminal domain of human SSRP1
To Be Published
6L1E
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BU of 6l1e by Molmil
Crystal structure of middle domain of hSSRP1
分子名称: FACT complex subunit SSRP1
著者Li, H.Y, Hu, T.T, Dou, Y.S, Su, D.
登録日2019-09-29
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.0939 Å)
主引用文献Crystal structure of middle domain of hSSRP1
To Be Published
6L34
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BU of 6l34 by Molmil
Crystal structure of the HMG domain of human FACT complex subunit SSRP1
分子名称: FACT complex subunit SSRP1
著者Li, H.Y, Hu, T.T, Dou, Y.S, Su, D.
登録日2019-10-09
公開日2020-10-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.996 Å)
主引用文献Crystal structure of the HMG domain of human FACT complex subunit SSRP1
To Be Published
1FAG
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BU of 1fag by Molmil
STRUCTURE OF CYTOCHROME P450
分子名称: CYTOCHROME P450 BM-3, PALMITOLEIC ACID, PROTOPORPHYRIN IX CONTAINING FE
著者Li, H.Y, Poulos, T.L.
登録日1996-08-01
公開日1997-02-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid.
Nat.Struct.Biol., 4, 1997
1FAH
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BU of 1fah by Molmil
STRUCTURE OF CYTOCHROME P450
分子名称: CYTOCHROME P450 BM-3, PROTOPORPHYRIN IX CONTAINING FE
著者Li, H.Y, Poulos, T.L.
登録日1996-08-01
公開日1997-02-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The role of Thr268 in oxygen activation of cytochrome P450BM-3.
Biochemistry, 34, 1995
2F5H
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BU of 2f5h by Molmil
Solution structure of the alpha-domain of human Metallothionein-3
分子名称: CADMIUM ION, Metallothionein-3
著者Wang, H, Zhang, Q, Cai, B, Li, H.Y, Sze, K.H, Huang, Z.X, Wu, H.M, Sun, H.Z.
登録日2005-11-25
公開日2006-05-30
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of human metallothionein-3 (MT-3)
Febs Lett., 580, 2006
5ONU
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BU of 5onu by Molmil
Trimeric OmpU structure
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, GLYCEROL, LAURYL DIMETHYLAMINE-N-OXIDE, ...
著者Li, H.Y, Dong, C.J.
登録日2017-08-04
公開日2018-01-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structure of the outer membrane protein OmpU from Vibrio cholerae at 2.2 angstrom resolution.
Acta Crystallogr D Struct Biol, 74, 2018
1NOO
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BU of 1noo by Molmil
CYTOCHROME P450-CAM COMPLEXED WITH 5-EXO-HYDROXYCAMPHOR
分子名称: 5-EXO-HYDROXYCAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE
著者Li, H.Y, Poulos, T.L.
登録日1995-12-02
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of Cytochrome P450-Cam Complexed with its Catalytic Product, 5-Exo-Hydroxycamphor
J.Am.Chem.Soc., 117, 1995
2H80
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BU of 2h80 by Molmil
NMR structures of SAM domain of Deleted in Liver Cancer 2 (DLC2)
分子名称: StAR-related lipid transfer protein 13
著者Li, H.Y, Fung, K.L, Jin, D.Y, Chung, S.S, Ko, B.C, Sun, H.Z.
登録日2006-06-06
公開日2007-05-15
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2
Proteins, 67, 2007
7NZN
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BU of 7nzn by Molmil
Structure of RET kinase domain bound to inhibitor JB-48
分子名称: 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret
著者Briggs, D.C, McDonald, N.Q.
登録日2021-03-24
公開日2022-02-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
J.Med.Chem., 65, 2022
2KW0
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BU of 2kw0 by Molmil
Solution structure of N-terminal domain of CcmH from Escherichia.coli
分子名称: CcmH protein
著者Hong, J, Zheng, X, Hu, H, Lin, D.
登録日2010-03-30
公開日2011-07-13
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Biochemical properties and catalytic domain structure of the CcmH protein from Escherichia coli.
Biochim.Biophys.Acta, 1824, 2012
6IVY
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BU of 6ivy by Molmil
Crystal structure of iron-bound HitA from Pseudomonas aeruginosa
分子名称: FE (III) ION, PHOSPHATE ION, Periplasmic Ferric iron-binding Protein HitA
著者Zhang, Z.R, Li, H.Y.
登録日2018-12-04
公開日2019-12-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9999994 Å)
主引用文献Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.
Acs Infect Dis., 5, 2019
1RW8
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BU of 1rw8 by Molmil
Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor
分子名称: 3-(4-FLUOROPHENYL)-2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE, TGF-beta receptor type I
著者Zhang, F, Sawyer, J.S.
登録日2003-12-16
公開日2005-02-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Bioorg.Med.Chem.Lett., 14, 2004
1PY5
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BU of 1py5 by Molmil
Crystal Structure of TGF-beta receptor I kinase with inhibitor
分子名称: 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE, SULFATE ION, TGF-beta receptor type I
著者Zhang, F, Sawyer, J.S.
登録日2003-07-08
公開日2004-07-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Bioorg.Med.Chem.Lett., 14, 2004
4YVS
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BU of 4yvs by Molmil
crystal structure of the virus-like particle of a c4 strain EV71
分子名称: Capsid protein VP0, Capsid protein VP1, Capsid protein VP3
著者Chen, R, Lyu, K.
登録日2015-03-20
公開日2015-04-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease
J.Virol., 89, 2015
4YVW
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BU of 4yvw by Molmil
crystal structure of an enterovirus 71/coxsackievirus A16 chimeric virus-like particle
分子名称: Capsid protein VP0, Capsid protein VP1, Capsid protein VP3
著者Chen, R, Lyu, K.
登録日2015-03-20
公開日2015-04-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease
J.Virol., 89, 2015

 

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