6AGB
| Cryo-EM structure of yeast Ribonuclease P | 分子名称: | RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ... | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | 登録日 | 2018-08-10 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
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6AH3
| Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ... | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | 登録日 | 2018-08-16 | 公開日 | 2018-10-17 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
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7C7A
| Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1 | 分子名称: | Internal Transcribed Spacer 1, MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, ... | 著者 | Lan, P, Wu, J, Lei, M. | 登録日 | 2020-05-24 | 公開日 | 2020-07-08 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP. Science, 369, 2020
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7C79
| Cryo-EM structure of yeast Ribonuclease MRP | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease MRP RNA subunit NME1, ... | 著者 | Lan, P, Wu, J, Lei, M. | 登録日 | 2020-05-24 | 公開日 | 2020-07-08 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP. Science, 369, 2020
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6AHV
| Crystal structure of human RPP40 | 分子名称: | Ribonuclease P protein subunit p40 | 著者 | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | 登録日 | 2018-08-20 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 175, 2018
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6AHR
| Cryo-EM structure of human Ribonuclease P | 分子名称: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | 著者 | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | 登録日 | 2018-08-20 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 175, 2018
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6AHU
| Cryo-EM structure of human Ribonuclease P with mature tRNA | 分子名称: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | 著者 | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | 登録日 | 2018-08-20 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 175, 2018
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5VWX
| Bak core latch dimer in complex with Bim-h0-h3Glt | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11 | 著者 | Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. | 登録日 | 2017-05-23 | 公開日 | 2017-11-15 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.489 Å) | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
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5VX0
| Bak in complex with Bim-h3Glg | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ... | 著者 | Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. | 登録日 | 2017-05-23 | 公開日 | 2017-11-15 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
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6K0B
| cryo-EM structure of archaeal Ribonuclease P with mature tRNA | 分子名称: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | 著者 | Wan, F, Lan, P, Wu, J, Lei, M. | 登録日 | 2019-05-05 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. Nat Commun, 10, 2019
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6K0A
| cryo-EM structure of an archaeal Ribonuclease P | 分子名称: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | 著者 | Wan, F, Lan, P, Wu, J, Lei, M. | 登録日 | 2019-05-05 | 公開日 | 2019-06-19 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. Nat Commun, 10, 2019
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7WTE
| Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2 | 分子名称: | ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ... | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | 登録日 | 2022-02-04 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
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7WTB
| Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | 登録日 | 2022-02-04 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
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7WTA
| Cryo-EM structure of human pyruvate carboxylase in apo state | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | 登録日 | 2022-02-04 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
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7WTD
| Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | 登録日 | 2022-02-04 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
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7WTC
| Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | 登録日 | 2022-02-04 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
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7D58
| cryo-EM structure of human RNA polymerase III in elongating state | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | 登録日 | 2020-09-25 | 公開日 | 2021-02-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into transcriptional regulation of human RNA polymerase III. Nat.Struct.Mol.Biol., 28, 2021
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7D59
| cryo-EM structure of human RNA polymerase III in apo state | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | 登録日 | 2020-09-25 | 公開日 | 2021-02-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into transcriptional regulation of human RNA polymerase III. Nat.Struct.Mol.Biol., 28, 2021
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5WYK
| Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 40S ribosomal protein S1-A, ... | 著者 | Ye, K, Zhu, X, Sun, Q. | 登録日 | 2017-01-13 | 公開日 | 2017-03-29 | 最終更新日 | 2017-05-17 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular architecture of the 90S small subunit pre-ribosome. Elife, 6, 2017
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5WYJ
| Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 40S ribosomal protein S1-A, ... | 著者 | Ye, K, Zhu, X, Sun, Q. | 登録日 | 2017-01-13 | 公開日 | 2017-03-29 | 最終更新日 | 2019-10-09 | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | 主引用文献 | Molecular architecture of the 90S small subunit pre-ribosome. Elife, 6, 2017
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5WY3
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7SVL
| DPP9 IN COMPLEX WITH LIGAND ICeD-2 | 分子名称: | (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 9 | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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7SVM
| DPP8 IN COMPLEX WITH LIGAND ICeD-2 | 分子名称: | (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 8, trimethylamine oxide | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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7SVN
| DPP9 IN COMPLEX WITH LIGAND ICeD-1 | 分子名称: | (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 9 | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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7SVO
| DPP8 IN COMPLEX WITH LIGAND ICeD-1 | 分子名称: | (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 8, trimethylamine oxide | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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