3BOF
 
 | | Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+ and Homocysteine | | 分子名称: | 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydrofolate S-homocysteine methyltransferase, POTASSIUM ION, ... | | 著者 | Koutmos, M, Smith, J.L, Ludwig, M.L. | | 登録日 | 2007-12-17 | | 公開日 | 2008-03-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Metal active site elasticity linked to activation of homocysteine in methionine synthases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3BOL
 | | Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+ | | 分子名称: | 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydrofolate S-homocysteine methyltransferase, POTASSIUM ION, ... | | 著者 | Koutmos, M, Smith, J.L, Ludwig, M.L. | | 登録日 | 2007-12-17 | | 公開日 | 2008-03-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Metal active site elasticity linked to activation of homocysteine in methionine synthases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3PC4
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3PC2
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3PC3
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3SBY
 | | Crystal Structure of SeMet-Substituted Apo-MMACHC (1-244), a human B12 processing enzyme | | 分子名称: | Methylmalonic aciduria and homocystinuria type C protein | | 著者 | Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. | | 登録日 | 2011-06-06 | | 公開日 | 2011-06-22 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
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3SC0
 | | Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin | | 分子名称: | CO-METHYLCOBALAMIN, Methylmalonic aciduria and homocystinuria type C protein | | 著者 | Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. | | 登録日 | 2011-06-06 | | 公開日 | 2011-06-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
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3SBZ
 | | Crystal Structure of Apo-MMACHC (1-244), a human B12 processing enzyme | | 分子名称: | GLYCEROL, MALONATE ION, Methylmalonic aciduria and homocystinuria type C protein | | 著者 | Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. | | 登録日 | 2011-06-06 | | 公開日 | 2011-06-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
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4M3P
 | | Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine | | 分子名称: | 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Betaine--homocysteine S-methyltransferase 1, POTASSIUM ION, ... | | 著者 | Koutmos, M, Yamada, K, Mladkova, J, Paterova, J, Diamond, C.E, Tryon, K, Jungwirth, P, Garrow, T.A, Jiracek, J. | | 登録日 | 2013-08-06 | | 公開日 | 2014-06-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.895 Å) | | 主引用文献 | Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase.
Proteins, 82, 2014
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3BUL
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3IV9
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3IVA
 | | Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half with AdoHcy bound | | 分子名称: | COBALAMIN, Methionine synthase, NITRATE ION, ... | | 著者 | Pattridge, K.A, Koutmos, M, Smith, J.L. | | 登録日 | 2009-08-31 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Insights into the reactivation of cobalamin-dependent methionine synthase.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4JYB
 | | MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP | | 分子名称: | Methylmalonyl-CoA mutase accessory protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Koutmos, M, Lofgren, M, Padovani, D, Banerjee, R. | | 登録日 | 2013-03-29 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone.
Nat.Chem.Biol., 9, 2013
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4JYC
 | | MeaB, A Bacterial Homolog of MMAA, in its Apo form | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Methylmalonyl-CoA mutase accessory protein | | 著者 | Koutmos, M, Lofgren, M, Padovani, D, Banerjee, R. | | 登録日 | 2013-03-29 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone.
Nat.Chem.Biol., 9, 2013
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4LC1
 | | MeaB, A Bacterial Homolog of MMAA, Bound to GDP and crystallized in the presence of GDP and [AlF4]- | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Methylmalonyl-CoA mutase accessory protein | | 著者 | Koutmos, M, Padovani, D, Lofgren, M, Banerjee, R. | | 登録日 | 2013-06-21 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 Enzyme.
J.Biol.Chem., 288, 2013
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4G25
 | | Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana, SeMet substituted form with Sr | | 分子名称: | Pentatricopeptide repeat-containing protein At2g32230, mitochondrial, STRONTIUM ION, ... | | 著者 | Koutmos, M, Howard, M.J, Fierke, C.A. | | 登録日 | 2012-07-11 | | 公開日 | 2012-09-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4G23
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4JGT
 | | Structure and kinetic analysis of H2S production by human Mercaptopyruvate Sulfurtransferase | | 分子名称: | 3-mercaptopyruvate sulfurtransferase, GLYCEROL, PYRUVIC ACID, ... | | 著者 | Koutmos, M, Yamada, K, Yadav, P.K, Chiku, T, Banerjee, R. | | 登録日 | 2013-03-03 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.161 Å) | | 主引用文献 | Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase.
J.Biol.Chem., 288, 2013
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4G24
 | | Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Mn | | 分子名称: | 6-AMINOHEXANOIC ACID, MANGANESE (II) ION, Pentatricopeptide repeat-containing protein At2g32230, ... | | 著者 | Koutmos, M, Howard, M.J, Fierke, C.A. | | 登録日 | 2012-07-11 | | 公開日 | 2012-09-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4G26
 | | Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Ca | | 分子名称: | CALCIUM ION, Pentatricopeptide repeat-containing protein At2g32230, mitochondrial, ... | | 著者 | Koutmos, M, Howard, M.J, Fierke, C.A. | | 登録日 | 2012-07-11 | | 公開日 | 2012-09-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
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5VOO
 | | Methionine synthase folate-binding domain with methyltetrahydrofolate from Thermus thermophilus HB8 | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate homocysteine S-methyltransferase, CHLORIDE ION, ... | | 著者 | Koutmos, M, Yamada, K. | | 登録日 | 2017-05-03 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.
Acta Crystallogr D Struct Biol, 74, 2018
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5VOP
 | | Methionine synthase folate-binding domain from Thermus thermophilus HB8 native | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate homocysteine S-methyltransferase, CITRATE ANION, ... | | 著者 | Koutmos, M, Yamada, K. | | 登録日 | 2017-05-03 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.
Acta Crystallogr D Struct Biol, 74, 2018
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8D32
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to 5-deoxyadenosylrhodibalamin and PPPi | | 分子名称: | 5'-DEOXYADENOSINE, Corrinoid adenosyltransferase, MAGNESIUM ION, ... | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2022-05-31 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A noble substitution leads to the cofactor mimicry by rhodibalamin
To Be Published
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8EAC
 | | Thermus thermophilus methylenetetrahydrofolate reductase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase | | 著者 | Yamada, K, Koutmos, M. | | 登録日 | 2022-08-28 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.
J.Biol.Chem., 299, 2022
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6U1R
 | | SxtG an amidinotransferase from the Microseira wollei in Saxitoxin biosynthetic pathway | | 分子名称: | FORMIC ACID, SxtG | | 著者 | Mallik, L, Lukowski, A.L, Narayan, A.R.H, Koutmos, M. | | 登録日 | 2019-08-16 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.792 Å) | | 主引用文献 | Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase.
Acs Chem.Biol., 15, 2020
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