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Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
分子名称:	TR109 heavy chain, TR109 light chain, TR92 heavy chain, ...
著者	Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K.
登録日	2022-11-29
公開日	2023-10-04
実験手法	ELECTRON MICROSCOPY (3.63 Å)
主引用文献	Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol, 6, 2023

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
分子名称:	Tumor necrosis factor
著者	Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日	2007-01-09
公開日	2007-11-13
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist J.Biol.Chem., 283, 2008

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
分子名称:	Tumor necrosis factor
著者	Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y.
登録日	2008-07-29
公開日	2009-03-24
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.83 Å)
主引用文献	Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists J.Biochem., 146, 2009

TNFR1 selectve TNF mutant; R1-6
分子名称:	GLYCEROL, Tumor necrosis factor
著者	Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日	2008-03-05
公開日	2009-01-20
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant J.Mol.Biol., 385, 2009