1K5S
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![BU of 1k5s by Molmil](/molmil-images/mine/1k5s) | PENICILLIN ACYLASE, MUTANT COMPLEXED WITH PPA | 分子名称: | CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, PENICILLIN G ACYLASE BETA SUBUNIT, ... | 著者 | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | 登録日 | 2001-10-12 | 公開日 | 2003-09-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase. Protein Eng.Des.Sel., 17, 2004
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1KEC
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![BU of 1kec by Molmil](/molmil-images/mine/1kec) | PENICILLIN ACYLASE MUTANT WITH PHENYL PROPRIONIC ACID | 分子名称: | CALCIUM ION, PENICILLIN ACYLASE ALPHA SUBUNIT, PENICILLIN ACYLASE BETA SUBUNIT, ... | 著者 | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | 登録日 | 2001-11-15 | 公開日 | 2003-09-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase. Protein Eng.Des.Sel., 17, 2004
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1K7D
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![BU of 1k7d by Molmil](/molmil-images/mine/1k7d) | Penicillin Acylase with Phenyl Proprionic Acid | 分子名称: | CALCIUM ION, Penicillin Acylase alpha subunit, R-2-PHENYL-PROPRIONIC ACID, ... | 著者 | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | 登録日 | 2001-10-19 | 公開日 | 2003-09-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase. Protein Eng.Des.Sel., 17, 2004
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1K5Q
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![BU of 1k5q by Molmil](/molmil-images/mine/1k5q) | PENICILLIN ACYLASE, MUTANT COMPLEXED WITH PAA | 分子名称: | 2-PHENYLACETIC ACID, CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, ... | 著者 | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | 登録日 | 2001-10-12 | 公開日 | 2003-09-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase. Protein Eng.Des.Sel., 17, 2004
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2X1D
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![BU of 2x1d by Molmil](/molmil-images/mine/2x1d) | The crystal structure of mature acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, ACETATE ION, ACYL-COENZYME, ... | 著者 | Bokhove, M, Yoshida, H, Hensgens, C.M.H, van der Laan, J.M, Sutherland, J.D, Dijkstra, B.W. | 登録日 | 2009-12-23 | 公開日 | 2010-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme. Structure, 18, 2010
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2X1C
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![BU of 2x1c by Molmil](/molmil-images/mine/2x1c) | The crystal structure of precursor acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum | 分子名称: | ACYL-COENZYME, CHLORIDE ION, GLYCEROL, ... | 著者 | Bokhove, M, Yoshida, H, Hensgens, C.M.H, van der Laan, J.M, Sutherland, J.D, Dijkstra, B.W. | 登録日 | 2009-12-23 | 公開日 | 2010-03-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme. Structure, 18, 2010
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2X1E
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![BU of 2x1e by Molmil](/molmil-images/mine/2x1e) | The crystal structure of mature acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum in complex 6- aminopenicillanic acid | 分子名称: | (2S,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, ACYL-COENZYME, CHLORIDE ION, ... | 著者 | Bokhove, M, Yoshida, H, Hensgens, C.M.H, van der Laan, J.M, Sutherland, J.D, Dijkstra, B.W. | 登録日 | 2009-12-23 | 公開日 | 2010-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme. Structure, 18, 2010
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1JX9
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![BU of 1jx9 by Molmil](/molmil-images/mine/1jx9) | Penicillin Acylase, mutant | 分子名称: | CALCIUM ION, penicillin G acylase alpha subunit, penicillin G acylase beta subunit | 著者 | Hensgens, C.M.H, Keizer, E, Snijder, H.J, Dijkstra, B.W. | 登録日 | 2001-09-06 | 公開日 | 2003-09-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase. Protein Eng.Des.Sel., 17, 2004
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1BK0
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![BU of 1bk0 by Molmil](/molmil-images/mine/1bk0) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE COMPLEX) | 分子名称: | FE (III) ION, ISOPENICILLIN N SYNTHASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | 著者 | Roach, P.L, Clifton, I.J, Hensgens, C.M.H, Shibata, N, Schofield, C.J, Hajdu, J, Baldwin, J.E. | 登録日 | 1998-07-14 | 公開日 | 1999-01-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature, 387, 1997
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1BLZ
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![BU of 1blz by Molmil](/molmil-images/mine/1blz) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX) | 分子名称: | FE (III) ION, ISOPENICILLIN N SYNTHASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | 著者 | Roach, P.L, Clifton, I.J, Hensgens, C.M.H, Shibata, N, Schofield, C.J, Hajdu, J, Baldwin, J.E. | 登録日 | 1998-07-22 | 公開日 | 1999-01-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature, 387, 1997
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1QIQ
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![BU of 1qiq by Molmil](/molmil-images/mine/1qiq) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACmC Fe COMPLEX) | 分子名称: | FE (III) ION, ISOPENICILLIN N SYNTHASE, N-[N-[2-AMINO-6-OXO-HEXANOIC ACID-6-YL]CYSTEINYL]-S-METHYLCYSTEINE, ... | 著者 | Rutledge, P.J, Clifton, I.J, Burzlaff, N.I, Roach, P.L, Adlington, R.M, Baldwin, J.E. | 登録日 | 1999-06-15 | 公開日 | 2000-06-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction. Nature, 401, 1999
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1QJF
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![BU of 1qjf by Molmil](/molmil-images/mine/1qjf) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (Monocyclic Sulfoxide - Fe COMPLEX) | 分子名称: | 1-[(1S)-CARBOXY-2-(METHYLSULFINYL)ETHYL]-(3R)-[(5S)-5-AMINO-5-CARBOXYPENTANAMIDO]-(4R)-SULFANYLAZETIDIN-2-ONE, FE (II) ION, ISOPENICILLIN N SYNTHASE, ... | 著者 | Rutledge, P.J, Clifton, I.J, Burzlaff, N.I, Roach, P.L, Adlington, R.M, Baldwin, J.E. | 登録日 | 1999-06-23 | 公開日 | 2000-06-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction Nature, 401, 1999
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1QJE
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![BU of 1qje by Molmil](/molmil-images/mine/1qje) | Isopenicillin N synthase from Aspergillus nidulans (IP1 - Fe complex) | 分子名称: | FE (II) ION, ISOPENICILLIN N, ISOPENICILLIN N SYNTHASE, ... | 著者 | Burzlaff, N.I, Clifton, I.J, Rutledge, P.J, Roach, P.L, Adlington, R.M, Baldwin, J.E. | 登録日 | 1999-06-23 | 公開日 | 2000-06-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction Nature, 401, 1999
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1HB1
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![BU of 1hb1 by Molmil](/molmil-images/mine/1hb1) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC ACOV FE COMPLEX) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHASE, N6-[(1R)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOMETHYL)-2-OXOETHYL]-6-OXO-D-LYSINE, ... | 著者 | Ogle, J.M, Clifton, I.J, Rutledge, P.J, Elkins, J.M, Burzlaff, N.I, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2001-04-11 | 公開日 | 2001-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction. Chem.Biol., 8, 2001
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1MPX
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![BU of 1mpx by Molmil](/molmil-images/mine/1mpx) | ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE | 分子名称: | CALCIUM ION, GLYCEROL, alpha-amino acid ester hydrolase | 著者 | Barends, T.R.M, Polderman-Tijmes, J.J, Jekel, P.A, Hensgens, C.M.H, de Vries, E.J, Janssen, D.B, Dijkstra, B.W. | 登録日 | 2002-09-13 | 公開日 | 2003-04-15 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases. J.Biol.Chem., 278, 2003
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1HB4
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![BU of 1hb4 by Molmil](/molmil-images/mine/1hb4) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, ... | 著者 | Ogle, J.M, Clifton, I.J, Rutledge, P.J, Elkins, J.M, Burzlaff, N.I, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2001-04-11 | 公開日 | 2001-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction. Chem.Biol., 8, 2001
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1HB3
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![BU of 1hb3 by Molmil](/molmil-images/mine/1hb3) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, ... | 著者 | Ogle, J.M, Clifton, I.J, Rutledge, P.J, Elkins, J.M, Burzlaff, N.I, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2001-04-11 | 公開日 | 2001-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction. Chem.Biol., 8, 2001
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1HB2
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![BU of 1hb2 by Molmil](/molmil-images/mine/1hb2) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN EXPOSED PRODUCT FROM ANAEROBIC ACOV FE COMPLEX) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHASE, N6-[(1S)-2-{[(1R)-1-CARBOXY-2-METHYLPROPYL]OXY}-1-(MERCAPTOCARBONYL)-2-OXOETHYL]-6-OXO-L-LYSINE, ... | 著者 | Ogle, J.M, Clifton, I.J, Rutledge, P.J, Elkins, J.M, Burzlaff, N.I, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2001-04-11 | 公開日 | 2001-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Alternative Oxidation by Isopenicillin N Synthase Observed by X-Ray Diffraction. Chem.Biol., 8, 2001
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1ODN
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![BU of 1odn by Molmil](/molmil-images/mine/1odn) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN-EXPOSED PRODUCT FROM ANAEROBIC AC-VINYLGLYCINE FE COMPLEX) | 分子名称: | 6-(5-AMINO-5-CARBOXY-PENTANOYLAMINO)-3-HYDROXYMETHYL-7-OXO-4-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, FE (II) ION, ISOPENICILLIN N SYNTHASE, ... | 著者 | Elkins, J.M, Rutledge, P.J, Burzlaff, N.I, Clifton, I.J, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2003-02-19 | 公開日 | 2003-06-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue Org.Biomol.Chem., 1, 2003
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1ODM
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![BU of 1odm by Molmil](/molmil-images/mine/1odm) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC AC-VINYLGLYCINE FE COMPLEX) | 分子名称: | DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHASE, ... | 著者 | Elkins, J.M, Rutledge, P.J, Burzlaff, N.I, Clifton, I.J, Adlington, R.M, Roach, P.L, Baldwin, J.E. | 登録日 | 2003-02-19 | 公開日 | 2003-06-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue Org.Biomol.Chem., 1, 2003
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2JB4
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![BU of 2jb4 by Molmil](/molmil-images/mine/2jb4) | Isopenicillin N synthase with a 2-thiabicycloheptan-6-one product analogue | 分子名称: | (1S,4S,5S,7R)-7-{[(5S)-5-AMINO-5-CARBOXYPENTANOYL]AMINO}-3,3-DIMETHYL-6-OXO-2-THIABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID, FE (III) ION, GLYCEROL, ... | 著者 | Stewart, A.C, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J. | 登録日 | 2006-12-01 | 公開日 | 2007-10-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | A Cyclobutanone Analogue Mimics Penicillin in Binding to Isopenicillin N Synthase. Chembiochem, 8, 2007
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