6NJH
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![BU of 6njh by Molmil](/molmil-images/mine/6njh) | Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48 | 分子名称: | 2-(4-{[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino}phenyl)acetamide, MAGNESIUM ION, ZINC ION, ... | 著者 | Fox III, D, Fairman, J.W, Gurney, M.E. | 登録日 | 2019-01-03 | 公開日 | 2019-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J.Med.Chem., 62, 2019
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6NJJ
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![BU of 6njj by Molmil](/molmil-images/mine/6njj) | Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN14770 | 分子名称: | (4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Fox III, D, Fairman, J.W, Gurney, M.E. | 登録日 | 2019-01-03 | 公開日 | 2019-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J.Med.Chem., 62, 2019
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6NJI
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![BU of 6nji by Molmil](/molmil-images/mine/6nji) | Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49 | 分子名称: | 2-(4-{[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino}phenyl)ethan-1-ol, MAGNESIUM ION, ZINC ION, ... | 著者 | Fox III, D, Fairman, J.W, Gurney, M.E. | 登録日 | 2019-01-03 | 公開日 | 2019-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J.Med.Chem., 62, 2019
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6BOJ
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![BU of 6boj by Molmil](/molmil-images/mine/6boj) | Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(4-{[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl}phenyl)acetamide, CHLORIDE ION, ... | 著者 | Fox III, D, Fairman, J.W, Gurney, M.E. | 登録日 | 2017-11-20 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice. Neuropsychopharmacology, 43, 2018
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4NW7
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![BU of 4nw7 by Molmil](/molmil-images/mine/4nw7) | PDE4 catalytic domain | 分子名称: | (4-{[4-(3-chlorophenyl)-6-cyclopropyl-1,3,5-triazin-2-yl]amino}phenyl)acetic acid, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Fox III, D, Edwards, T.E. | 登録日 | 2013-12-05 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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4MYQ
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![BU of 4myq by Molmil](/molmil-images/mine/4myq) | |
3BL9
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![BU of 3bl9 by Molmil](/molmil-images/mine/3bl9) | Synthetic Gene Encoded DcpS bound to inhibitor DG157493 | 分子名称: | 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | 著者 | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | 登録日 | 2007-12-10 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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3BL7
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![BU of 3bl7 by Molmil](/molmil-images/mine/3bl7) | Synthetic Gene Encoded DcpS bound to inhibitor DG156844 | 分子名称: | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | 著者 | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | 登録日 | 2007-12-10 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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3BLA
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![BU of 3bla by Molmil](/molmil-images/mine/3bla) | Synthetic Gene Encoded DcpS bound to inhibitor DG153249 | 分子名称: | 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | 著者 | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | 登録日 | 2007-12-10 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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3FH7
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![BU of 3fh7 by Molmil](/molmil-images/mine/3fh7) | |
3FH8
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![BU of 3fh8 by Molmil](/molmil-images/mine/3fh8) | |
3FTU
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![BU of 3ftu by Molmil](/molmil-images/mine/3ftu) | |
3FU6
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![BU of 3fu6 by Molmil](/molmil-images/mine/3fu6) | |
3FUN
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![BU of 3fun by Molmil](/molmil-images/mine/3fun) | |
3FUL
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![BU of 3ful by Molmil](/molmil-images/mine/3ful) | |
3FTS
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![BU of 3fts by Molmil](/molmil-images/mine/3fts) | Leukotriene A4 hydrolase in complex with resveratrol | 分子名称: | ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ... | 著者 | Davies, D.R. | 登録日 | 2009-01-13 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
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3FTY
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![BU of 3fty by Molmil](/molmil-images/mine/3fty) | |
3FUF
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![BU of 3fuf by Molmil](/molmil-images/mine/3fuf) | |
3FU3
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![BU of 3fu3 by Molmil](/molmil-images/mine/3fu3) | |
3G4I
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![BU of 3g4i by Molmil](/molmil-images/mine/3g4i) | Crystal structure of human phosphodiesterase 4d with d155871 | 分子名称: | 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ETHANOL, MAGNESIUM ION, ... | 著者 | Staker, B.L. | 登録日 | 2009-02-03 | 公開日 | 2010-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010
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3FTW
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![BU of 3ftw by Molmil](/molmil-images/mine/3ftw) | |
3FUD
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![BU of 3fud by Molmil](/molmil-images/mine/3fud) | |
3FUE
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![BU of 3fue by Molmil](/molmil-images/mine/3fue) | |
3G4L
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![BU of 3g4l by Molmil](/molmil-images/mine/3g4l) | Crystal structure of human phosphodiesterase 4d with roflumilast | 分子名称: | 1,2-ETHANEDIOL, 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE, MAGNESIUM ION, ... | 著者 | Staker, B.L. | 登録日 | 2009-02-03 | 公開日 | 2010-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010
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3G58
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![BU of 3g58 by Molmil](/molmil-images/mine/3g58) | |