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Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

1CIQ

COMPLEX OF TWO FRAGMENTS OF CI2, RESIDUES 1-40 AND 41-64
分子名称:	CHYMOTRYPSIN INHIBITOR 2
著者	Buckle, A.M, Fersht, A.R.
登録日	1995-10-02
公開日	1996-03-08
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism Structure Fold.Des., 1, 1996

2VUK

Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083
分子名称:	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Boeckler, F.M, Fersht, A.R.
登録日	2008-05-26
公開日	2008-07-22
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug. Proc.Natl.Acad.Sci.USA, 105, 2008

1JON

GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345
分子名称:	GROEL, HSP60 CLASS
著者	Buckle, A.M, Fersht, A.R.
登録日	1996-05-30
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. Proc.Natl.Acad.Sci.USA, 93, 1996

2VYR

Structure of human MDM4 N-terminal domain bound to a single domain antibody
分子名称:	HUMAN SINGLE DOMAIN ANTIBODY, MDM4 PROTEIN, SULFATE ION
著者	Yu, G.W, Vaysburd, M, Allen, M.D, Settanni, G, Fersht, A.R.
登録日	2008-07-28
公開日	2008-11-25
最終更新日	2013-03-06
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody. J.Mol.Biol., 385, 2009

1FY9

CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
分子名称:	60 KD CHAPERONIN, GLYCEROL
著者	Wang, Q, Buckle, A.M, Fersht, A.R.
登録日	2000-09-28
公開日	2000-11-22
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Stabilization of GroEL minichaperones by core and surface mutations. J.Mol.Biol., 298, 2000

1FYA

CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
分子名称:	60 KD CHAPERONIN, GLYCEROL
著者	Wang, Q, Buckle, A.M, Fersht, A.R.
登録日	2000-09-28
公開日	2000-11-22
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Stabilization of GroEL minichaperones by core and surface mutations. J.Mol.Biol., 298, 2000

2J20

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
分子名称:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者	Joerger, A.C, Ang, H.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1Z

Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J21

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1Y

Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
分子名称:	CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.69 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2FEJ

Solution structure of human p53 DNA binding domain.
分子名称:	Cellular tumor antigen p53, ZINC ION
著者	Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R.
登録日	2005-12-16
公開日	2006-01-31
最終更新日	2024-05-29
実験手法	SOLUTION NMR
主引用文献	Solution structure of p53 core domain: Structural basis for its instability Proc.Natl.Acad.Sci.Usa, 103, 2006

5LAP

p53 cancer mutant Y220C with Cys182 alkylation
分子名称:	5-chloranylpyrimidine-4-carboxylic acid, Cellular tumor antigen p53, ZINC ION
著者	Joerger, A.C, Bauer, M.R, Fersht, A.R.
登録日	2016-06-14
公開日	2016-08-10
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc.Natl.Acad.Sci.USA, 113, 2016

1UOL

Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Allen, M.D, Fersht, A.R.
登録日	2003-09-19
公開日	2003-10-16
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations J.Biol.Chem., 279, 2004

1HL2

Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
分子名称:	3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE SUBUNIT
著者	Joerger, A.C, Fersht, A.R.
登録日	2003-03-12
公開日	2003-05-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity Proc.Natl.Acad.Sci.USA, 100, 2003

2X0W

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole
分子名称:	5,6-DIMETHOXY-2-METHYL-1,3-BENZOTHIAZOLE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Kaar, J.L, Basse, N, Joerger, A.C, Fersht, A.R.
登録日	2009-12-17
公開日	2010-01-26
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010

2WGX

HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Khoo, K.H, Fersht, A.R.
登録日	2009-04-27
公開日	2009-05-12
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Stabilising the DNA-Binding Domain of P53 by Rational Design of its Hydrophobic Core. Protein Eng.Des.Sel., 22, 2009

2X0V

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine
分子名称:	4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Basse, N, Kaar, J.L, Joerger, A.C, Fersht, A.R.
登録日	2009-12-17
公開日	2010-01-26
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010

2X0U

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold
分子名称:	6,7-DIHYDRO[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Kaar, J.L, Basse, N, Fersht, A.R.
登録日	2009-12-17
公開日	2010-01-26
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010

5AOJ

Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid
分子名称:	2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
著者	Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.47 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

1KCQ

Human Gelsolin Domain 2 with a Cd2+ bound
分子名称:	CADMIUM ION, GELSOLIN
著者	Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R.
登録日	2001-11-09
公開日	2002-01-04
最終更新日	2023-08-16
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9, 2002

1KID

GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 191-376, MUTANT WITH ALA 262 REPLACED WITH LEU AND ILE 267 REPLACED WITH MET
分子名称:	GROEL (HSP60 CLASS)
著者	Buckle, A.M, Fersht, A.R.
登録日	1996-12-13
公開日	1997-09-17
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A structural model for GroEL-polypeptide recognition. Proc.Natl.Acad.Sci.USA, 94, 1997

2KZG

A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution
分子名称:	Pre-mRNA-processing factor 40 homolog A
著者	Korzhnev, D.M, Religa, T.L, Banachewicz, W, Fersht, A.R, Kay, L.E.
登録日	2010-06-17
公開日	2010-09-29
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	A transient and low-populated protein-folding intermediate at atomic resolution. Science, 329, 2010

2L9V

NMR structure of the FF domain L24A mutant's folding transition state
分子名称:	Pre-mRNA-processing factor 40 homolog A
著者	Korzhnev, D.M, Vernon, R.M, Religa, T.L, Hansen, A, Baker, D, Fersht, A.R, Kay, L.E.
登録日	2011-02-24
公開日	2011-09-28
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study. J.Am.Chem.Soc., 133, 2011

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