7TXT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7txt by Molmil](/molmil-images/mine/7txt) | Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl | 分子名称: | 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine, 15B8 Fab heavy chain, 15B8 Fab light chain, ... | 著者 | Singh, I, Seth, A, Billesboelle, C.B, Braz, J, Rodriguiz, R.M, Roy, K, Bekele, B, Craik, V, Huang, X.P, Boytsov, D, Lak, P, O'Donnell, H, Sandtner, W, Roth, B.L, Basbaum, A.I, Wetsel, W.C, Manglik, A, Shoichet, B.K, Rudnick, G. | 登録日 | 2022-02-09 | 公開日 | 2023-03-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell, 186, 2023
|
|
7W6P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w6p by Molmil](/molmil-images/mine/7w6p) | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist | 分子名称: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | 登録日 | 2021-12-02 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
|
|
7W7E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w7e by Molmil](/molmil-images/mine/7w7e) | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | 分子名称: | 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | 登録日 | 2021-12-04 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
|
|
7M95
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m95 by Molmil](/molmil-images/mine/7m95) | Bovine sigma-2 receptor bound to Z1241145220 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[1-(3-phenylpropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine, CHOLESTEROL, ... | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
|
|
7MFI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mfi by Molmil](/molmil-images/mine/7mfi) | Bovine sigma-2 receptor bound to cholesterol | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-04-09 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
|
|
7M94
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m94 by Molmil](/molmil-images/mine/7m94) | Bovine sigma-2 receptor bound to Roluperidone | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Roluperidone, Sigma intracellular receptor 2 | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
|
|
7M93
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m93 by Molmil](/molmil-images/mine/7m93) | Bovine sigma-2 receptor bound to PB28 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PB28, Sigma intracellular receptor 2 | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
|
|
7M96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m96 by Molmil](/molmil-images/mine/7m96) | Bovine sigma-2 receptor bound to Z4857158944 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-({[(1S)-1-hydroxy-2-methyl-1-phenylpropan-2-yl]amino}methyl)-1-methyl-3,4-dihydroquinolin-2(1H)-one, ... | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
|
|