5TGJ
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5TGI
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8TXY
| X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera | 分子名称: | DI(HYDROXYETHYL)ETHER, N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, SULFATE ION, ... | 著者 | Raymond, D.D, Lemke, C.T, Shaffer, P.L, Collins, B, Steele, R, Seierstad, M. | 登録日 | 2023-08-24 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc.Natl.Acad.Sci.USA, 121, 2024
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6E8R
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5E7F
| Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06) | 分子名称: | Major structural protein 1, nanobody L06 | 著者 | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | 登録日 | 2015-10-12 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
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5E7T
| Structure of the tripod (BppUct-A-L) from the baseplate of bacteriophage Tuc2009 | 分子名称: | CALCIUM ION, Major structural protein 1, Minor structural protein 4, ... | 著者 | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | 登録日 | 2015-10-13 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
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5E7B
| Structure of a nanobody (vHH) from camel against phage Tuc2009 RBP (BppL, ORF53) | 分子名称: | nanobody nano-L06 | 著者 | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | 登録日 | 2015-10-12 | 公開日 | 2015-12-30 | 最終更新日 | 2016-05-04 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
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3PSN
| Crystal structure of mouse VPS29 complexed with Mn2+ | 分子名称: | MANGANESE (II) ION, Vacuolar protein sorting-associated protein 29 | 著者 | Swarbrick, J, Shaw, D, Chhabra, S, Ghai, R, Valkov, E, Norwood, S, Collins, B. | 登録日 | 2010-12-02 | 公開日 | 2010-12-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Conformational dynamics and biomolecular interactions of VPS29 studied by NMR and X-ray crystallography To be Published
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3PSO
| Crystal structure of mouse VPS29 complexed with Zn2+ | 分子名称: | Vacuolar protein sorting-associated protein 29, ZINC ION | 著者 | Swarbrick, J, Shaw, D, Chhabra, S, Ghai, R, Valkov, E, Norwood, S, Collins, B. | 登録日 | 2010-12-02 | 公開日 | 2010-12-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Conformational dynamics and biomolecular interactions of VPS29 studied by NMR and X-ray crystallography To be Published
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3KEC
| Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound | 分子名称: | 4-{[({3-[2-(4-methoxybenzyl)-2H-tetrazol-5-yl]phenyl}carbonyl)amino]methyl}benzoic acid, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | 著者 | Shieh, H.-S, Pavlovsky, A.G, Collins, B, Schnute, M.E. | 登録日 | 2009-10-25 | 公開日 | 2010-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2010
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3KEK
| Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound | 分子名称: | CALCIUM ION, Collagenase 3, ZINC ION, ... | 著者 | Shieh, H.-S, Collins, B, Schnute, M.E. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2009
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3KEJ
| Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound | 分子名称: | 4-[(5-{2-[(3-fluorobenzyl)carbamoyl]pyridin-4-yl}-2H-tetrazol-2-yl)methyl]benzoic acid, CALCIUM ION, Collagenase 3, ... | 著者 | Shieh, H.-S, Collins, B, Schnute, M.E. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2010
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6N5X
| Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1) | 分子名称: | GLYCEROL, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), Sorting nexin-5,Cation-independent mannose-6-phosphate receptor | 著者 | Collins, B, Paul, B, Weeratunga, S. | 登録日 | 2018-11-22 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.051 Å) | 主引用文献 | Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nat.Cell Biol., 21, 2019
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6N5Z
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6N5Y
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4QDH
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3LH9
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3LH8
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3LHA
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5TGH
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7JU8
| X-ray structure of MMP-13 in Complex with 4-(1,2,3-thiadiazol-4-yl)pyridine | 分子名称: | 4-(1,2,3-thiadiazol-4-yl)pyridine, CALCIUM ION, Collagenase 3, ... | 著者 | Farrow, N.A. | 登録日 | 2020-08-19 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Indole Inhibitors of MMP-13 for Arthritic Disorders Acs Omega, 6, 2021
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7PRW
| The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*AP*C)-3'), ... | 著者 | Postel, S, Edman, K, Wissler, L. | 登録日 | 2021-09-22 | 公開日 | 2023-02-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | 主引用文献 | Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30, 2023
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7PRV
| The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp | 分子名称: | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), ... | 著者 | Postel, S, Edman, K, Wissler, L. | 登録日 | 2021-09-22 | 公開日 | 2023-02-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30, 2023
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7PRX
| wildtype ligand binding domain of the glucocorticoid receptor complexed with velsecorat and a PGC1a coactivator fragment | 分子名称: | Glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Velsecorat | 著者 | Edman, K, Wissler, L, Koehler, C, Postel, S. | 登録日 | 2021-09-22 | 公開日 | 2023-02-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30, 2023
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4P2A
| Structure of mouse VPS26A bound to rat SNX27 PDZ domain | 分子名称: | MERCURY (II) ION, Sorting nexin-27, Vacuolar protein sorting-associated protein 26A | 著者 | Clairfeuille, T, Gallon, M, Mas, C, Ghai, R, Teasdale, R, Cullen, P, Collins, B. | 登録日 | 2014-03-03 | 公開日 | 2014-09-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc.Natl.Acad.Sci.USA, 111, 2014
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