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Structure of thymidylate synthase ThyX complexed to a new inhibitor
分子名称:	2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者	Basta, T, Boum, Y, Briffotaux, J, Becker, H.F, Lamarre-Jouenne, I, Lambry, J.C, Skouloubris, S, Liebl, U, van Tilbeurgh, H, Graille, M, Myllylkallio, H.
登録日	2012-07-06
公開日	2013-05-22
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.59 Å)
主引用文献	Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biology, 2, 2012

Crystal structure of His-tagged human thymidylate synthase R175A mutant
分子名称:	1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
著者	Pozzi, C, Mangani, S.
登録日	2013-05-14
公開日	2014-05-14
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.03 Å)
主引用文献	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015

Crystal structure of human thymidylate synthase Y202A in inactive conformation.
分子名称:	SULFATE ION, Thymidylate synthase
著者	Tochowicz, A, Stroud, R.M, Wade, R.C.
登録日	2013-02-26
公開日	2014-08-20
最終更新日	2015-05-06
実験手法	X-RAY DIFFRACTION (2.311 Å)
主引用文献	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015