4FZB

Structure of thymidylate synthase ThyX complexed to a new inhibitor

Summary for 4FZB

• Entry DOI: 10.2210/pdb4fzb/pdb
• Descriptor: Probable thymidylate synthase, FLAVIN-ADENINE DINUCLEOTIDE, 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione, ... (5 entities in total)
• Functional Keywords: homotetramer, fad-dependent thymidylate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Paramecium bursaria Chlorella virus 1 (PBCV-1)
• Total number of polymer chains: 16
• Total formula weight: 437697.38

Authors

Basta, T.,Boum, Y.,Briffotaux, J.,Becker, H.F.,Lamarre-Jouenne, I.,Lambry, J.C.,Skouloubris, S.,Liebl, U.,van Tilbeurgh, H.,Graille, M.,Myllylkallio, H. (deposition date: 2012-07-06, release date: 2013-05-22, Last modification date: 2023-09-13)

• Primary citation: Basta, T.,Boum, Y.,Briffotaux, J.,Becker, H.F.,Lamarre-Jouenne, I.,Lambry, J.C.,Skouloubris, S.,Liebl, U.,Graille, M.,van Tilbeurgh, H.,Myllykallio, H.; Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.; Open Biology, 2:120120-120120, 2012; PubMed: 23155486; DOI: 10.1098/rsob.120120

Experimental method

X-RAY DIFFRACTION (2.59 Å)