6D08
 
 | | Crystal structure of an engineered bump-hole complex of mutant human chromobox homolog 1 (CBX1) with H3K9bn peptide | | 分子名称: | Chromobox protein homolog 1, GLYCEROL, Histone H3.1, ... | | 著者 | Arora, S, Horne, W.S, Islam, K. | | 登録日 | 2018-04-10 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions.
J.Am.Chem.Soc., 141, 2019
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6D07
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5CEH
 | | Structure of histone lysine demethylase KDM5A in complex with selective inhibitor | | 分子名称: | 7-oxo-5-phenyl-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, Lysine-specific demethylase 5A, NICKEL (II) ION, ... | | 著者 | Kiefer, J.R, Vinogradova, M. | | 登録日 | 2015-07-06 | | 公開日 | 2016-05-18 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
Nat.Chem.Biol., 12, 2016
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7UN7
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6XRX
 | | Crystal structure of the mosquito protein AZ1 as an MBP fusion | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Pedersen, L.C, Mueller, G.A, Foo, A.C.Y. | | 登録日 | 2020-07-14 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6W45
 | | Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 | | 分子名称: | 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl)carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | | 著者 | Ferguson, A.D. | | 登録日 | 2020-03-10 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
J.Med.Chem., 64, 2021
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6W44
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6W4C
 | | Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 | | 分子名称: | 5-[[3-[3-(dimethylamino)-1,2,4-oxadiazol-5-yl]-2-oxidanyl-phenyl]methylamino]-2~{H}-indazole-3-carboxylic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | | 著者 | Ferguson, A.D. | | 登録日 | 2020-03-10 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
J.Med.Chem., 64, 2021
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5KR7
 | | KDM4C bound to pyrazolo-pyrimidine scaffold | | 分子名称: | 6-ethyl-2,5-dimethyl-7-oxidanylidene-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, FE (II) ION, ... | | 著者 | Bellon, S.F, Poy, F, Setser, J.W. | | 登録日 | 2016-07-07 | | 公開日 | 2016-08-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Identification of potent, selective KDM5 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
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5KG9
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