6DFT
| Trypanosoma brucei deoxyhypusine synthase | 分子名称: | Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Tomchick, D.R, Phillips, M.A, Afanador, G.A. | 登録日 | 2018-05-15 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs. Structure, 26, 2018
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5T8U
| Crystal structure of P. falciparum LipL1 in complex lipoate | 分子名称: | LIPOIC ACID, Lipoate-protein ligase 1 | 著者 | Guerra, A.J, Afanador, G.A, Prigge, S.T. | 登録日 | 2016-09-08 | 公開日 | 2017-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.324 Å) | 主引用文献 | Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum. Proteins, 85, 2017
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4O1M
| Toxoplasma gondii Enoyl acyl carrier protein reductase | 分子名称: | Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Muench, S.P, Wilkinson, C, Prigge, S.T, Rice, D.W. | 登録日 | 2013-12-16 | 公開日 | 2014-02-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target Bioorg.Med.Chem.Lett., 24, 2014
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6E0B
| Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | 分子名称: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Tomchick, D.R, Phillips, M.A, Deng, X. | 登録日 | 2018-07-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
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