7FAW
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![BU of 7faw by Molmil](/molmil-images/mine/7faw) | Structure of LW domain from Yeast | 分子名称: | Transcription elongation factor S-II | 著者 | Liao, S, Gao, J, Tu, X. | 登録日 | 2021-07-07 | 公開日 | 2022-07-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | 主引用文献 | Structural basis for evolutionarily conserved interactions between TFIIS and Paf1C. Int.J.Biol.Macromol., 253, 2023
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5TWL
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![BU of 5twl by Molmil](/molmil-images/mine/5twl) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one, Maternal embryonic leucine zipper kinase | 著者 | Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S. | 登録日 | 2016-11-14 | 公開日 | 2017-11-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6, 2017
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5TWZ
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4N97
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![BU of 4n97 by Molmil](/molmil-images/mine/4n97) | |
5V3M
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5V3J
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![BU of 5v3j by Molmil](/molmil-images/mine/5v3j) | mouseZFP568-ZnF1-10 in complex with DNA | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (26-MER), MAGNESIUM ION, ... | 著者 | Patel, A, Cheng, X. | 登録日 | 2017-03-07 | 公開日 | 2018-03-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.064 Å) | 主引用文献 | DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Cell, 173, 2018
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5TX3
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![BU of 5tx3 by Molmil](/molmil-images/mine/5tx3) | Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one, Maternal embryonic leucine zipper kinase | 著者 | Li, Q, Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S, Eck, M.J. | 登録日 | 2016-11-15 | 公開日 | 2017-11-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6, 2017
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7WLK
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![BU of 7wlk by Molmil](/molmil-images/mine/7wlk) | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-[diethyl(methyl)-$l^{4}-azanyl]ethyl 4-[(2-octoxyphenyl)carbonylamino]benzoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
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7WLL
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![BU of 7wll by Molmil](/molmil-images/mine/7wll) | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
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7WLI
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![BU of 7wli by Molmil](/molmil-images/mine/7wli) | CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
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7WLJ
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![BU of 7wlj by Molmil](/molmil-images/mine/7wlj) | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB) | 分子名称: | (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
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7D0E
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![BU of 7d0e by Molmil](/molmil-images/mine/7d0e) | Crystal structure of FIP200 Claw/p-CCPG1 FIR2 | 分子名称: | 3-(2-hydroxyethyloxy)-2-[2-(2-hydroxyethyloxy)ethoxymethyl]-2-(2-hydroxyethyloxymethyl)propan-1-ol, Cell cycle progression protein 1 FIR2, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zhou, Z.X, Pan, L.F. | 登録日 | 2020-09-09 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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7CZG
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![BU of 7czg by Molmil](/molmil-images/mine/7czg) | Crystal structure of FIP200 Claw domain apo form | 分子名称: | DI(HYDROXYETHYL)ETHER, RB1-inducible coiled-coil protein 1 | 著者 | Zhou, Z.X, Pan, L.F. | 登録日 | 2020-09-08 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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7CZM
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5V6O
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4KY8
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![BU of 4ky8 by Molmil](/molmil-images/mine/4ky8) | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional thymidylate synthase-dihydrofolate reductase, METHOTREXATE, ... | 著者 | Kumar, V.P, Anderson, K.S. | 登録日 | 2013-05-28 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.084 Å) | 主引用文献 | Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4N94
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![BU of 4n94 by Molmil](/molmil-images/mine/4n94) | E. coli sliding clamp in complex with 3,4-difluorobenzamide | 分子名称: | 1,2-ETHANEDIOL, 3,4-difluorobenzamide, CALCIUM ION, ... | 著者 | Yin, Z, Oakley, A.J. | 登録日 | 2013-10-19 | 公開日 | 2013-11-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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7FAX
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4MBI
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![BU of 4mbi by Molmil](/molmil-images/mine/4mbi) | Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors | 分子名称: | N,N-dimethyl-N'-[3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]ethane-1,2-diamine, Serine/threonine-protein kinase pim-1 | 著者 | Azevedo, R, Fischmann, T.O. | 登録日 | 2013-08-19 | 公開日 | 2013-09-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach. Bioorg.Med.Chem.Lett., 23, 2013
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8K3G
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5TI9
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![BU of 5ti9 by Molmil](/molmil-images/mine/5ti9) | Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161 | 分子名称: | N'-Formylkynurenine, OXYGEN MOLECULE, PHOSPHATE ION, ... | 著者 | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | 登録日 | 2016-10-01 | 公開日 | 2016-10-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6, 2016
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5TIA
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![BU of 5tia by Molmil](/molmil-images/mine/5tia) | Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase | 著者 | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | 登録日 | 2016-10-01 | 公開日 | 2016-10-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.441 Å) | 主引用文献 | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6, 2016
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4N99
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![BU of 4n99 by Molmil](/molmil-images/mine/4n99) | E. coli sliding clamp in complex with 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid | 分子名称: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Yin, Z, Oakley, A.J. | 登録日 | 2013-10-19 | 公開日 | 2013-11-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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6JV3
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6JV5
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