4RKF
| Drosophila melanogaster Rab3 bound to GMPPNP | 分子名称: | MAGNESIUM ION, PENTAETHYLENE GLYCOL, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. | 登録日 | 2014-10-13 | 公開日 | 2014-12-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun, 71, 2015
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4RZ9
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3SBS
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3SBT
| Crystal structure of a Aar2-Prp8 complex | 分子名称: | A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, S-1,2-PROPANEDIOL, ... | 著者 | Weber, G, Santos, K.F, Holton, N, Wahl, M.C. | 登録日 | 2011-06-06 | 公開日 | 2011-07-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
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3PGW
| Crystal structure of human U1 snRNP | 分子名称: | DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... | 著者 | Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. | 登録日 | 2010-11-02 | 公開日 | 2010-12-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Functional organization of the Sm core in the crystal structure of human U1 snRNP. Embo J., 29, 2010
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3SBG
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3ST3
| Dreiklang - off state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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3SIU
| Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form | 分子名称: | NHP2-like protein 1, SULFATE ION, U4/U6 small nuclear ribonucleoprotein Prp31, ... | 著者 | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | 登録日 | 2011-06-20 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.626 Å) | 主引用文献 | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
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3SIV
| Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form | 分子名称: | NHP2-like protein 1, U4/U6 small nuclear ribonucleoprotein Prp31, U4atac snRNA | 著者 | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | 登録日 | 2011-06-20 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | 主引用文献 | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
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3ST2
| Dreiklang - equilibrium state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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3ST4
| Dreiklang - on state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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7BDK
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | 登録日 | 2020-12-21 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDL
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ADP | 分子名称: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | 登録日 | 2020-12-21 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDJ
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS | 分子名称: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | 登録日 | 2020-12-21 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDI
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | 登録日 | 2020-12-21 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7FJX
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A01 from the F2X-Universal Library | 分子名称: | A1 cistron-splicing factor AAR2, N-cyclohexyl-2-(1H-pyrazol-1-yl)acetamide, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FJV
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P03H10 from the F2X-Universal Library | 分子名称: | (3S)-3-amino-4-(2-fluorophenyl)butanoic acid, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FJY
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A02 from the F2X-Universal Library | 分子名称: | 1-[(3-aminophenyl)methyl]piperidin-4-ol, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FK2
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A07 from the F2X-Universal Library | 分子名称: | 4-(thiophene-2-sulfonyl)morpholine, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FK7
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04B04 from the F2X-Universal Library | 分子名称: | A1 cistron-splicing factor AAR2, N-cyclopropyl-1-methyl-N-(2-methylpropyl)-1H-pyrazole-4-sulfonamide, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FKC
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04C10 from the F2X-Universal Library | 分子名称: | A1 cistron-splicing factor AAR2, N,N~2~-dimethyl-N-(pyridin-2-yl)glycinamide, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FKI
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04D08 from the F2X-Universal Library | 分子名称: | (2R)-(3,4-difluorophenyl)(hydroxy)acetic acid, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FKJ
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04D11 from the F2X-Universal Library | 分子名称: | 5-chloro-N,1-dimethyl-N-[(2S)-pentan-2-yl]-1H-imidazole-4-sulfonamide, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FKN
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04E05 from the F2X-Universal Library | 分子名称: | A1 cistron-splicing factor AAR2, P-HYDROXYACETOPHENONE, Pre-mRNA-splicing factor 8 | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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7FK3
| PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A09 from the F2X-Universal Library | 分子名称: | A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, methyl N-(benzenesulfonyl)-N-methylglycinate | 著者 | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | 登録日 | 2022-08-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022
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