4MDE
 
 | | Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA | | 分子名称: | DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | | 登録日 | 2013-08-22 | | 公開日 | 2013-11-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition.
Nucleic Acids Res., 42, 2014
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3HCM
 | | Crystal structure of human S100B in complex with S45 | | 分子名称: | (3R)-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]piperidine, ACETATE ION, CALCIUM ION, ... | | 著者 | Mangani, S, Cesari, L. | | 登録日 | 2009-05-06 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fragmenting the S100B-p53 Interaction: Combined Virtual/Biophysical Screening Approaches to Identify Ligands
Chemmedchem, 5, 2010
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6NHX
 | | mycobacterial DNA ligase D complexed with ATP and MES | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase | | 著者 | Shuman, S, Unciuleac, M, Goldgur, Y. | | 登録日 | 2018-12-24 | | 公開日 | 2019-02-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 294, 2019
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2QY2
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6VDD
 | | POL domain of Pol1 from M. smegmatis complex with DNA primer-template and dNTP | | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A*(DCT))-3'), DNA (5'-D(P*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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7UFV
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 | | 分子名称: | (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION | | 著者 | Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-03-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of Nanomolar DCAF1 Small Molecule Ligands.
J.Med.Chem., 66, 2023
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6VDC
 | | POL domain of Pol1 from M. smegmatis | | 分子名称: | DNA polymerase I, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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6VDE
 | | Full-length M. smegmatis Pol1 | | 分子名称: | DNA polymerase I, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.713 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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7TB1
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7T8J
 | | The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a GSGG linker | | 分子名称: | CHLORIDE ION, Transcription factor ETV6,Non-receptor tyrosine-protein kinase TNK1 | | 著者 | Soleimani, S, Pedroza Romo, M.J, Smith, T, Brown, S, Doukov, T, Moody, J.D. | | 登録日 | 2021-12-16 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
Structure, 31, 2023
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6TZX
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | INOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.529 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6U03
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6U00
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | PHOSPHATE ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.981 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6TZO
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-12 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6TZM
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-12 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.714 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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7UD5
 | | Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | | 分子名称: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | | 登録日 | 2022-03-18 | | 公開日 | 2022-09-21 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | | 主引用文献 | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6U05
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6CVM
 | | Atomic resolution cryo-EM structure of beta-galactosidase | | 分子名称: | 2-phenylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, MAGNESIUM ION, ... | | 著者 | Subramaniam, S, Bartesaghi, A, Banerjee, S, Zhu, X, Milne, J.L.S. | | 登録日 | 2018-03-28 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | Atomic Resolution Cryo-EM Structure of beta-Galactosidase.
Structure, 26, 2018
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4BPG
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8U8L
 | | X-ray crystal structure of TEBP-2 MCD3 with ds DNA | | 分子名称: | CESIUM ION, DNA (5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*CP*TP*TP*AP*GP*GP*CP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*GP*CP*CP*TP*AP*AP*GP*CP*CP*TP*AP*AP*CP*A)-3'), ... | | 著者 | Nandakumar, J, Padmanaban, S. | | 登録日 | 2023-09-18 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U8M
 | | X-ray crystal structure of TEBP-1 MCD2 homodimer | | 分子名称: | COBALT (II) ION, Double-strand telomeric DNA-binding proteins 1 | | 著者 | Nandakumar, J, Padmanaban, S. | | 登録日 | 2023-09-18 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6C35
 | | Mycobacterium smegmatis flap endonuclease mutant D148N | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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6C33
 | | Mycobacterium smegmatis DNA flap endonuclease | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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6C34
 | | Mycobacterium smegmatis DNA flap endonuclease mutant D125N | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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5ND5
 | | Crystal structure of transketolase from Chlamydomonas reinhardtii in complex with TPP and Mg2+ | | 分子名称: | MAGNESIUM ION, THIAMINE DIPHOSPHATE, Transketolase | | 著者 | Fermani, S, Zaffagnini, M, Francia, F, Pasquini, M. | | 登録日 | 2017-03-07 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural basis for the magnesium-dependent activation of transketolase from Chlamydomonas reinhardtii.
Biochim. Biophys. Acta, 1861, 2017
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