7TB1

Crystal structure of STUB1 with a macrocyclic peptide

Summary for 7TB1

Entry DOI	10.2210/pdb7tb1/pdb
Descriptor	E3 ubiquitin-protein ligase CHIP, ALA-CYS-SER-SER-ILE-TRP-CYS-PRO-ASP-GLY, 1,3-bis(sulfanyl)propan-2-one, ... (4 entities in total)
Functional Keywords	e3 ligase, carboxy-terminus of hsp70-interacting protein, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	33906.45
Authors	Bahmanjah, S.,Klein, D.J. (deposition date: 2021-12-21, release date: 2022-07-27, Last modification date: 2023-10-18)
Primary citation	Ng, S.,Brueckner, A.C.,Bahmanjah, S.,Deng, Q.,Johnston, J.M.,Ge, L.,Duggal, R.,Habulihaz, B.,Barlock, B.,Ha, S.,Sadruddin, A.,Yeo, C.,Strickland, C.,Peier, A.,Henry, B.,Sherer, E.C.,Partridge, A.W. Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1. J.Med.Chem., 2022 Cited by PubMed: 35853179 DOI: 10.1021/acs.jmedchem.2c00406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.785 Å)

Structure validation