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Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 10
分子名称:	Inositol polyphosphate multikinase, N-{4-[(5P)-5-(1H-tetrazol-5-yl)-2,1-benzoxazol-3-yl]phenyl}cyclopropanecarboxamide
著者	Wang, H, Shears, S.B.
登録日	2023-12-04
公開日	2024-12-11
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Structure-based development of IPMK kinase inhibitors. To Be Published

8V6Y

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 3
分子名称:	3-(3,5-dimethylphenyl)-2,1-benzoxazole-5-carboxylic acid, Inositol polyphosphate multikinase
著者	Wang, H, Shears, S.B.
登録日	2023-12-04
公開日	2024-12-11
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structure-based development of IPMK kinase inhibitors. To Be Published

8V76

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 12
分子名称:	Inositol polyphosphate multikinase, N-{(3P)-3-[(5P)-5-(2H-tetrazol-5-yl)-2,1-benzoxazol-3-yl]phenyl}cyclopentanecarboxamide, SULFATE ION
著者	Wang, H, Shears, S.B.
登録日	2023-12-04
公開日	2024-12-11
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structure-based development of IPMK kinase inhibitors. To Be Published

8V78

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 14
分子名称:	(3P,5M)-3-{3-[(3,5-dichloropyridin-2-yl)oxy]phenyl}-5-(1H-tetrazol-5-yl)-2,1-benzoxazole, Inositol polyphosphate multikinase
著者	Wang, H, Shears, S.B.
登録日	2023-12-04
公開日	2024-12-11
実験手法	X-RAY DIFFRACTION (1.96 Å)
主引用文献	Structure-based development of IPMK kinase inhibitors. To Be Published

5VJ6

BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195
分子名称:	8ANC195 Fab heavy chain, 8ANC195 Fab light chain, Envelope glycoprotein gp160, ...
著者	Wang, H, Bjorkman, P.J.
登録日	2017-04-18
公開日	2017-06-21
最終更新日	2024-10-30
実験手法	ELECTRON MICROSCOPY (11.5 Å)
主引用文献	Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies. Elife, 6, 2017

8H1M

Crystal structure of glucose-2-epimerase mutant_D254A from Runella slithyformis Runsl_4512
分子名称:	FORMIC ACID, N-acylglucosamine 2-epimerase
著者	Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M.
登録日	2022-10-03
公開日	2023-07-12
最終更新日	2024-05-29
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023

8H1N

Crystal structure of glucose-2-epimerase mutant_D254A in complex with D-Glucitol from Runella slithyformis Runsl_4512
分子名称:	FORMIC ACID, N-acylglucosamine 2-epimerase, sorbitol
著者	Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M.
登録日	2022-10-03
公開日	2023-07-12
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.67 Å)
主引用文献	Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023

5W2I

Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP
分子名称:	ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
著者	Wang, H, Shears, S.B.
登録日	2017-06-06
公開日	2017-09-13
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J. Biol. Chem., 292, 2017

5W2H

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
分子名称:	ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
著者	Wang, H, Shears, S.B.
登録日	2017-06-06
公開日	2017-09-13
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J. Biol. Chem., 292, 2017

7ZSA

Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP (complex B)
分子名称:	DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者	Wang, H, Cramer, P.
登録日	2022-05-06
公開日	2022-11-16
最終更新日	2025-07-02
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023

7ZSB

Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C
分子名称:	DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者	Wang, H, Cramer, P.
登録日	2022-05-06
公開日	2022-11-16
最終更新日	2025-07-02
実験手法	ELECTRON MICROSCOPY (6.6 Å)
主引用文献	Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023

7ZS9

Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A)
分子名称:	DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者	Wang, H, Cramer, P.
登録日	2022-05-06
公開日	2022-11-16
最終更新日	2025-07-09
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023

3T9A

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 7.0
分子名称:	CADMIUM ION, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T9E

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP, 5-(PP)-IP5 (5-IP7) and MgF3 (transition state mimic)
分子名称:	(1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, ADENOSINE-5'-DIPHOSPHATE, Inositol Pyrophosphate Kinase, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T54

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ATP and Cadmium
分子名称:	ADENOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Inositol Pyrophosphate Kinase
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-07-26
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T9B

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 5.2
分子名称:	Inositol Pyrophosphate Kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T9D

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and 5-(PP)-IP5 (5-IP7)
分子名称:	(1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3USI

Crystal structure of LeuT bound to L-leucine in space group P2 from lipid bicelles
分子名称:	LEUCINE, SODIUM ION, Transporter
著者	Wang, H, Elferich, J, Gouaux, E.
登録日	2011-11-23
公開日	2012-01-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (3.106 Å)
主引用文献	Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012

3USK

Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles
分子名称:	LEUCINE, SODIUM ION, Transporter
著者	Wang, H, Elferich, J, Gouaux, E.
登録日	2011-11-23
公開日	2012-01-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (4.5 Å)
主引用文献	Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012

3USL

Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles
分子名称:	ACETATE ION, IODIDE ION, PHOSPHOCHOLINE, ...
著者	Wang, H, Elferich, J, Gouaux, E.
登録日	2011-11-23
公開日	2012-01-11
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.71 Å)
主引用文献	Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012

3T7A

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2
分子名称:	1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-07-29
公開日	2011-12-07
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T9F

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)
分子名称:	(1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

3T9C

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and inositol hexakisphosphate (IP6)
分子名称:	INOSITOL HEXAKISPHOSPHATE, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
著者	Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
登録日	2011-08-02
公開日	2011-12-07
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011

5YXA

Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus
分子名称:	Non-structural protein 1
著者	Wang, H, Song, H, Qi, J, Shi, Y, Gao, G.F.
登録日	2017-12-04
公開日	2018-01-24
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus. Sci China Life Sci, 60, 2017

3USO

Crystal structure of LeuT bound to L-selenomethionine in space group P21212 from lipid bicelles
分子名称:	SELENOMETHIONINE, SODIUM ION, Transporter
著者	Wang, H, Elferich, J, Gouaux, E.
登録日	2011-11-23
公開日	2012-01-11
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (4.5 Å)
主引用文献	Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012

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