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5JGA
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Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 11c
分子名称: N-[5-(4-methylpiperazine-1-carbonyl)[1,1'-biphenyl]-2-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide, TAK1 kinase - TAB1 chimera fusion protein
著者Irie, M, Nakamura, M, Fukami, T.A, Matsuura, T, Morishima, K.
登録日2016-04-19
公開日2016-07-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of a potent and highly selective transforming growth factor beta receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)
Bioorg.Med.Chem., 24, 2016
7FB7
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Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, DIMETHYL SULFOXIDE, ...
著者Kori, S, Arita, K, Yoshimi, S.
登録日2021-07-08
公開日2022-01-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Bioorg.Med.Chem., 52, 2021
8W85
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HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQN0385AE01 Fab heavy chain, DQN0385AE01 Fab light chain, ...
著者Irie, M, Tsushima, T, Teranishi-Ikawa, Y, Takahashi, N, Ishii, S, Okura, Y, Fukami, T.A, Torizawa, T.
登録日2023-08-31
公開日2023-11-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.769 Å)
主引用文献Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Nat Commun, 14, 2023
8W86
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HLA-DQ2.5-B/C hordein peptide in complex with DQN0385AE02
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQN0385AE02 Fab heavy chain, DQN0385AE02 Fab light chain, ...
著者Irie, M, Tsushima, T, Teranishi-Ikawa, Y, Takahashi, N, Ishii, S, Okura, Y, Fukami, T.A, Torizawa, T.
登録日2023-08-31
公開日2023-11-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.236 Å)
主引用文献Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Nat Commun, 14, 2023
8W84
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HLA-DQ2.5-alpha2 gliadin peptide in complex with DQN0344AE02
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQN0344AE02 Fab heavy chain, DQN0344AE02 Fab light chain, ...
著者Irie, M, Tsushima, T, Teranishi-Ikawa, Y, Takahashi, N, Ishii, S, Okura, Y, Fukami, T.A, Torizawa, T.
登録日2023-08-31
公開日2023-11-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Nat Commun, 14, 2023
8W83
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HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQN0344AE02 Fab heavy chain, DQN0344AE02 Fab light chain, ...
著者Irie, M, Tsushima, T, Teranishi-Ikawa, Y, Takahashi, N, Ishii, S, Okura, Y, Fukami, T.A, Torizawa, T.
登録日2023-08-31
公開日2023-11-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.818 Å)
主引用文献Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Nat Commun, 14, 2023
8IBR
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BU of 8ibr by Molmil
Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis in complex with glycerol
分子名称: Beta-galactosidase, DI(HYDROXYETHYL)ETHER, GLYCEROL
著者Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T.
登録日2023-02-10
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
8IBT
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Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis E318S mutant in complex with lacto-N-tetraose
分子名称: Beta-galactosidase, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T.
登録日2023-02-10
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
8IBS
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Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis E160A/E318A mutant in complex with galactose
分子名称: Beta-galactosidase, alpha-D-galactopyranose
著者Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T.
登録日2023-02-10
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
3WEC
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BU of 3wec by Molmil
Structure of P450 RauA (CYP1050A1) complexed with a biosynthetic intermediate of aurachin RE
分子名称: 3-[(2E,6E,9R)-9-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-2-methylquinolin-4(1H)-one, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Yasutake, Y, Kitagawa, W, Tamura, T.
登録日2013-07-03
公開日2014-01-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids
Febs Lett., 588, 2014
6IP5
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BU of 6ip5 by Molmil
Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T.
登録日2018-11-02
公開日2019-05-29
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
6JLZ
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BU of 6jlz by Molmil
P-eIF2a - eIF2B complex
分子名称: Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ...
著者Kashiwagi, K, Ito, T.
登録日2019-03-07
公開日2019-05-01
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
6PAZ
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OXIDIZED MUTANT P80I PSEUDOAZURIN FROM A. FAECALIS
分子名称: COPPER (II) ION, PSEUDOAZURIN
著者Adman, E.T, Libeu, C.A.P.
登録日1997-02-21
公開日1997-08-20
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences.
Biochemistry, 36, 1997
7F67
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BU of 7f67 by Molmil
eIF2B-SFSV NSs-2-eIF2
分子名称: Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ...
著者Kashiwagi, K, Ito, T.
登録日2021-06-24
公開日2021-12-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nat Commun, 12, 2021
7F66
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eIF2B-SFSV NSs-1-eIF2
分子名称: Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ...
著者Kashiwagi, K, Ito, T.
登録日2021-06-24
公開日2021-12-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nat Commun, 12, 2021
7F64
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eIF2B-SFSV NSs
分子名称: Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
著者Kashiwagi, K, Ito, T.
登録日2021-06-24
公開日2021-12-08
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.42 Å)
主引用文献eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nat Commun, 12, 2021
1CYD
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BU of 1cyd by Molmil
CARBONYL REDUCTASE COMPLEXED WITH NADPH AND 2-PROPANOL
分子名称: CARBONYL REDUCTASE, ISOPROPYL ALCOHOL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Tanaka, N, Nonaka, T, Mitsui, Y.
登録日1995-09-01
公開日1996-10-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
Structure, 4, 1996
7PAZ
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REDUCED MUTANT P80I PSEUDOAZURIN FROM A. FAECALIS
分子名称: COPPER (II) ION, PSEUDOAZURIN
著者Adman, E.T, Libeu, C.A.P.
登録日1997-02-21
公開日1997-08-20
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences.
Biochemistry, 36, 1997
7YV1
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BU of 7yv1 by Molmil
Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor LUNA18 and KA30L Fab
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, KA30L Fab H-chain, ...
著者Irie, M, Fukami, T.A, Matsuo, A, Saka, K, Nishimura, M, Saito, H, Torizawa, T, Tanada, M, Ohta, A.
登録日2022-08-18
公開日2023-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.454 Å)
主引用文献Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J.Am.Chem.Soc., 145, 2023
8PAZ
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OXIDIZED NATIVE PSEUDOAZURIN FROM A. FAECALIS
分子名称: COPPER (II) ION, PSEUDOAZURIN
著者Adman, E.T, Libeu, C.A.P.
登録日1997-02-24
公開日1997-08-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences.
Biochemistry, 36, 1997
1BDM
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BU of 1bdm by Molmil
THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY
分子名称: BETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MALATE DEHYDROGENASE
著者Kelly, C.A, Birktoft, J.J.
登録日1993-02-16
公開日1994-12-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.
Biochemistry, 32, 1993
1DLF
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BU of 1dlf by Molmil
HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI-DANSYL SWITCH VARIANT ANTIBODY IGG2A(S) CRYSTALLIZED AT PH 5.25
分子名称: ANTI-DANSYL IMMUNOGLOBULIN IGG2A(S), SULFATE ION
著者Nakasako, M, Takahashi, H, Shimada, I, Arata, Y.
登録日1998-07-14
公開日1999-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The pH-dependent structural variation of complementarity-determining region H3 in the crystal structures of the Fv fragment from an anti-dansyl monoclonal antibody.
J.Mol.Biol., 291, 1999
1NTD
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STRUCTURE OF ALCALIGENES FAECALIS NITRITE REDUCTASE MUTANT M150E THAT CONTAINS ZINC
分子名称: COPPER (II) ION, NITRITE REDUCTASE
著者Murphy, M.E.P, Adman, E.T, Turley, S.
登録日1995-07-03
公開日1996-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc.
Biochemistry, 34, 1995
2AFN
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BU of 2afn by Molmil
STRUCTURE OF ALCALIGENES FAECALIS NITRITE REDUCTASE AND A COPPER SITE MUTANT, M150E, THAT CONTAINS ZINC
分子名称: COPPER (II) ION, NITRITE REDUCTASE
著者Murphy, M.E.P, Adman, E.T, Turley, S.
登録日1995-07-03
公開日1996-08-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc.
Biochemistry, 34, 1995
5PAZ
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REDUCED MUTANT P80A PSEUDOAZURIN FROM A. FAECALIS
分子名称: COPPER (II) ION, PSEUDOAZURIN
著者Adman, E.T, Libeu, C.A.P.
登録日1997-02-21
公開日1997-08-20
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences.
Biochemistry, 36, 1997

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