8W85

HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01

Summary for 8W85

• Entry DOI: 10.2210/pdb8w85/pdb
• Descriptor: DQN0385AE01 Fab heavy chain, DQN0385AE01 Fab light chain, HLA class II histocompatibility antigen, DQ alpha 1 chain, ... (5 entities in total)
• Functional Keywords: celiac disease, antibody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 188170.58

Authors

Irie, M.,Tsushima, T.,Teranishi-Ikawa, Y.,Takahashi, N.,Ishii, S.,Okura, Y.,Fukami, T.A.,Torizawa, T. (deposition date: 2023-08-31, release date: 2023-11-08, Last modification date: 2024-01-10)

• Primary citation: Okura, Y.,Ikawa-Teranishi, Y.,Mizoroki, A.,Takahashi, N.,Tsushima, T.,Irie, M.,Harfuddin, Z.,Miura-Okuda, M.,Ito, S.,Nakamura, G.,Takesue, H.,Ozono, Y.,Nishihara, M.,Yamada, K.,Gan, S.W.,Hayasaka, A.,Ishii, S.,Wakabayashi, T.,Muraoka, M.,Nagaya, N.,Hino, H.,Nemoto, T.,Kuramochi, T.,Torizawa, T.,Shimada, H.,Kitazawa, T.,Okazaki, M.,Nezu, J.,Sollid, L.M.,Igawa, T.; Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease; Nat Commun, 14:8502-, 2023; DOI: 10.1038/s41467-023-44083-4

Experimental method

X-RAY DIFFRACTION (2.769 Å)