8A1H
| Bacterial 6-4 photolyase from Vibrio cholerase | 分子名称: | 1-deoxy-1-(6,7-dimethyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-4 photolyase (FeS-BCP, ... | 著者 | Essen, L.-O, Emmerich, H.J. | 登録日 | 2022-06-01 | 公開日 | 2023-02-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural and Functional Analysis of a Prokaryotic (6-4) Photolyase from the Aquatic Pathogen Vibrio Cholerae † . Photochem.Photobiol., 99, 2023
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8A8L
| Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment | 分子名称: | 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, Cytochrome P450 protein, GLYCEROL, ... | 著者 | Snee, M, Katariya, M, Levy, C. | 登録日 | 2022-06-23 | 公開日 | 2023-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment To Be Published
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8A6W
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7ZFM
| Engineered Protein Targeting the Zika Viral Envelope Fusion Loop | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, HEXAETHYLENE GLYCOL, ... | 著者 | Athayde, D, Archer, M, Viana, I.F.T, Adan, W.C.S, Xavier, L.S.S, Lins, R.D. | 登録日 | 2022-04-01 | 公開日 | 2022-08-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.711 Å) | 主引用文献 | In Vitro Neutralisation of Zika Virus by an Engineered Protein Targeting the Viral Envelope Fusion Loop SSRN, 2022
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7ZFR
| Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide bound in the reverse direction | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DP alpha chain (DPA1*02:01), MHC class II HLA-DP beta chain (DPB1*01:01), ... | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | 登録日 | 2022-04-01 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
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7ZJV
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7ZJU
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8B1V
| Dihydroprecondylocarpine acetate synthase 2 from Tabernanthe iboga | 分子名称: | Dihydroprecondylocarpine acetate synthase 2, ZINC ION, precondylocarpine acetate | 著者 | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | 登録日 | 2022-09-12 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | 主引用文献 | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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7ZAK
| Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MAGNESIUM ION, ... | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | 登録日 | 2022-03-22 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
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8AKK
| Acyl-enzyme complex of imipenem bound to deacylation mutant KPC-2 (E166Q) | 分子名称: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2022-07-29 | 公開日 | 2023-03-08 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145, 2023
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8AKM
| Acyl-enzyme complex of ertapenem bound to deacylation mutant KPC-2 (E166Q) | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, Ertapenem, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2022-07-29 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145, 2023
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8AKJ
| Acyl-enzyme complex of cephalothin bound to deacylation mutant KPC-2 (E166Q) | 分子名称: | 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2022-07-29 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145, 2023
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8QI7
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8R61
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8RZC
| SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 11 | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-imidazol-1-yl-benzoic acid, ... | 著者 | Kalnins, G. | 登録日 | 2024-02-12 | 公開日 | 2024-02-21 | 最終更新日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors. Chemmedchem, 2024
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8RZD
| SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 9 | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-(3-hydroxyphenyl)benzoic acid, ... | 著者 | Kalnins, G. | 登録日 | 2024-02-12 | 公開日 | 2024-02-21 | 最終更新日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors. Chemmedchem, 2024
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8RZE
| SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 10 | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-pyridin-3-yl-benzoic acid, ... | 著者 | Kalnins, G. | 登録日 | 2024-02-12 | 公開日 | 2024-02-21 | 最終更新日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors. Chemmedchem, 2024
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8S0B
| H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0F
| H. sapiens OC1M bound to double stranded DNA | 分子名称: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0A
| H. sapiens MCM2-7 hexamer bound to double stranded DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0D
| H. sapiens MCM bound to double stranded DNA and ORC1-6 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (58-mer), DNA replication licensing factor MCM2, ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0C
| H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | 分子名称: | DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0E
| H. sapiens OCCM bound to double stranded DNA | 分子名称: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S09
| H. sapiens MCM2-7 double hexamer bound to double stranded DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | 登録日 | 2024-02-13 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8R15
| Crystal structure of Fusarium oxysporum NADase I | 分子名称: | GLYCEROL, TNT domain-containing protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | 登録日 | 2023-11-01 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage. Protein Sci., 33, 2024
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