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7DL6
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BU of 7dl6 by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 18
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
著者Wei, T, Xiao, J.
登録日2020-11-26
公開日2021-12-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.648 Å)
主引用文献Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
4NIE
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BU of 4nie by Molmil
Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand
分子名称: 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ...
著者Ma, Y.L, Yang, L.Q.
登録日2013-11-06
公開日2013-12-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists.
Acs Med.Chem.Lett., 5, 2014
1HNY
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BU of 1hny by Molmil
The structure of human pancreatic alpha-amylase at 1.8 angstroms resolution and comparisons with related enzymes
分子名称: CALCIUM ION, CHLORIDE ION, HUMAN PANCREATIC ALPHA-AMYLASE
著者Luo, Y, Brayer, G.D.
登録日1995-06-28
公開日1996-03-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.
Protein Sci., 4, 1995
6CKH
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BU of 6ckh by Molmil
Manduca sexta Peptidoglycan Recognition Protein-1
分子名称: Peptidoglycan-recognition protein
著者Hu, Y.
登録日2018-02-28
公開日2019-06-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The three-dimensional structure and recognition mechanism of Manduca sexta peptidoglycan recognition protein-1.
Insect Biochem.Mol.Biol., 108, 2019
7UKC
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BU of 7ukc by Molmil
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region
分子名称: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKH
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BU of 7ukh by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region
分子名称: CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ...
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.33 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKE
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BU of 7uke by Molmil
Human Kv4.2-KChIP2 channel complex in an intermediate state, transmembrane region
分子名称: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UK5
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BU of 7uk5 by Molmil
Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region
分子名称: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-03-31
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKG
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BU of 7ukg by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
分子名称: Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.24 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKF
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BU of 7ukf by Molmil
Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region
分子名称: MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKD
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BU of 7ukd by Molmil
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region
分子名称: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
著者Zhao, H, Dai, Y, Lee, C.H.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7V5G
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BU of 7v5g by Molmil
20S+monoUb-CyclinB1-NT (S1)
分子名称: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
著者Xu, C, Cong, Y.
登録日2021-08-17
公開日2021-09-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (4.47 Å)
主引用文献The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag.
Nat Commun, 12, 2021
7V5M
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BU of 7v5m by Molmil
20S+monoUb-CyclinB1-NT (S2)
分子名称: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
著者Xu, C, Cong, Y.
登録日2021-08-17
公開日2021-09-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.88 Å)
主引用文献The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag.
Nat Commun, 12, 2021
8WBX
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BU of 8wbx by Molmil
Cryo-EM structure of the ABCG25 bound to ABA
分子名称: (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABC transporter G family member 25
著者Xin, J, Yan, K.G.
登録日2023-09-10
公開日2023-09-27
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural insights into AtABCG25, an angiosperm-specific abscisic acid exporter.
Plant Commun., 5, 2024
8WAM
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BU of 8wam by Molmil
Cryo-EM structure of the ABCG25 E232Q mutant bound to ATP and Magnesium
分子名称: ABC transporter G family member 25, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Xin, J, Yan, K.G.
登録日2023-09-07
公開日2023-09-27
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural insights into AtABCG25, an angiosperm-specific abscisic acid exporter.
Plant Commun., 5, 2024
8WD6
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BU of 8wd6 by Molmil
Cryo-EM structure of the ABCG25
分子名称: ABC transporter G family member 25
著者Xin, J, Yan, K.G.
登録日2023-09-14
公開日2023-09-27
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Structural insights into AtABCG25, an angiosperm-specific abscisic acid exporter.
Plant Commun., 5, 2024
8WBA
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BU of 8wba by Molmil
Cryo-EM structure of the ABCG25 bound to CHS
分子名称: ABC transporter G family member 25, CHOLESTEROL HEMISUCCINATE
著者Xin, J, Yan, K.G.
登録日2023-09-09
公開日2023-09-27
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into AtABCG25, an angiosperm-specific abscisic acid exporter.
Plant Commun., 5, 2024
7WG6
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BU of 7wg6 by Molmil
Neutral Omicron Spike Trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Cui, Z, Wang, X.
登録日2021-12-28
公開日2022-05-18
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
6G76
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BU of 6g76 by Molmil
Phosphorylated RSK4 N-terminal Kinase Domain in complex with AMP-PNP
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-6, ZINC ION
著者Prischi, F, Ali, M.M.
登録日2018-04-04
公開日2019-04-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Sci Transl Med, 13, 2021
7EKQ
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BU of 7ekq by Molmil
CrClpP-S2c
分子名称: ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit, ...
著者Wang, N, Wang, Y.F, Cong, Y, Liu, C.M.
登録日2021-04-06
公開日2021-10-20
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献The cryo-EM structure of the chloroplast ClpP complex.
Nat.Plants, 7, 2021
7EKO
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BU of 7eko by Molmil
CrClpP-S1
分子名称: ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit
著者Wang, N, Wang, Y.F, Cong, Y, Liu, C.M.
登録日2021-04-06
公開日2021-10-20
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The cryo-EM structure of the chloroplast ClpP complex.
Nat.Plants, 7, 2021
4N70
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BU of 4n70 by Molmil
Pim1 Complexed with a pyridylcarboxamide
分子名称: N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, Serine/threonine-protein kinase pim-1
著者Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D.
登録日2013-10-14
公開日2013-11-06
最終更新日2014-07-02
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
2JYF
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BU of 2jyf by Molmil
Tetraloop-receptor RNA complex
分子名称: RNA (43-MER)
著者Zuo, X, Wang, J, Foster, T.R, Schwieters, C.D, Tiede, D.M.
登録日2007-12-13
公開日2008-10-07
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Tetraloop-receptor RNA complex
To be Published
3Q7L
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BU of 3q7l by Molmil
Crystal structure of the E2 domain of amyloid precursor-like protein 1
分子名称: Amyloid-like protein 1, SULFATE ION
著者Xue, Y, Ha, Y.
登録日2011-01-05
公開日2011-06-29
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate.
J.Biol.Chem., 286, 2011
6G78
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BU of 6g78 by Molmil
RSK4 N-terminal Kinase Domain S232E in complex with AMP-PNP
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-6
著者Prischi, F, Ali, M.M.
登録日2018-04-04
公開日2019-04-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Sci Transl Med, 13, 2021

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