2PJY
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2Q11
| Structure of BACE complexed to compound 1 | 分子名称: | 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE, Beta-secretase 1 | 著者 | Sharff, A.J. | 登録日 | 2007-05-23 | 公開日 | 2007-08-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. J.Med.Chem., 50, 2007
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2PG2
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2Q15
| Structure of BACE complexed to compound 3a | 分子名称: | (4S)-4-(2-AMINO-6-PHENOXYQUINAZOLIN-3(4H)-YL)-N,4-DICYCLOHEXYL-N-METHYLBUTANAMIDE, Beta-secretase 1 | 著者 | Sharff, A.J. | 登録日 | 2007-05-23 | 公開日 | 2007-08-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. J.Med.Chem., 50, 2007
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1T14
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4HQX
| CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4) | 分子名称: | MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ... | 著者 | Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C. | 登録日 | 2012-10-26 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc.Natl.Acad.Sci.USA, 109, 2012
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5LPR
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4I53
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4JLC
| Crystal structure of mouse TBK1 bound to SU6668 | 分子名称: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | 著者 | Li, P. | 登録日 | 2013-03-12 | 公開日 | 2013-06-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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4JKM
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4JY4
| Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody | 分子名称: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PGT121 heavy chain, ... | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | 登録日 | 2013-03-29 | 公開日 | 2013-05-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathog., 9, 2013
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4JM2
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4IWD
| Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog | 分子名称: | 1-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)methanesulfonamide, Hepatocyte growth factor receptor | 著者 | Soisson, S.M, Northrup, A, Rickert, K, Patel, S, Allison, T. | 登録日 | 2013-01-23 | 公開日 | 2013-12-11 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. J.Med.Chem., 56, 2013
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4JY6
| Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody | 分子名称: | GLYCEROL, PGT123 heavy chain, PGT123 light chain, ... | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | 登録日 | 2013-03-29 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans. Plos Pathog., 9, 2013
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4JL9
| Crystal structure of mouse TBK1 bound to BX795 | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | 著者 | Li, P, Shu, C. | 登録日 | 2013-03-12 | 公開日 | 2013-06-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.0999 Å) | 主引用文献 | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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4JM4
| Crystal Structure of PGT 135 Fab | 分子名称: | PGT 135 Heavy Chain, PGT 135 Light Chain | 著者 | Kong, L, Wilson, I.A. | 登録日 | 2013-03-13 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat.Struct.Mol.Biol., 20, 2013
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4JPJ
| Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | 著者 | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | 登録日 | 2013-03-19 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4JKL
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4JIO
| Bro1 V domain and ubiquitin | 分子名称: | BRO1, Ubiquitin | 著者 | Pashkova, N, Gakhar, L, Piper, R.C. | 登録日 | 2013-03-06 | 公開日 | 2013-06-19 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The yeast alix homolog bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev.Cell, 25, 2013
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4JJY
| Alix V domain | 分子名称: | Programmed cell death 6-interacting protein | 著者 | Pashkova, N, Gakhar, L, Yu, L, Piper, R.C. | 登録日 | 2013-03-08 | 公開日 | 2013-06-19 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (6.503 Å) | 主引用文献 | The yeast alix homolog bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev.Cell, 25, 2013
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4JPI
| Crystal structure of a putative VRC01 germline precursor Fab | 分子名称: | GLYCEROL, Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain | 著者 | Julien, J.-P, Diwanji, D.C, Jardine, J, Schief, W.R, Wilson, I.A. | 登録日 | 2013-03-19 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4JPK
| Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... | 著者 | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | 登録日 | 2013-03-19 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4HYX
| Crystal Structure Analysis of the Bacteriorhodopsin in Facial Amphiphile-4 DMPC Bicelle | 分子名称: | Bacteriorhodopsin, DECANE, GLYCEROL, ... | 著者 | Lee, S, Stout, C.D, Zhang, Q. | 登録日 | 2012-11-14 | 公開日 | 2013-03-20 | 最終更新日 | 2013-05-22 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HWL
| Crystal Structure Analysis of the Bacteriorhodopsin in Facial Amphiphile-7 DMPC Bicelle | 分子名称: | Bacteriorhodopsin, GLYCEROL, HEPTANE, ... | 著者 | Lee, S, Stout, C.D, Zhang, Q. | 登録日 | 2012-11-08 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JY5
| Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody | 分子名称: | GLYCEROL, PGT122 heavy chain, PGT122 light chain | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | 登録日 | 2013-03-29 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathog., 9, 2013
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