7VPD
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7VO0
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7VO9
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7VPZ
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7XGL
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![BU of 7xgl by Molmil](/molmil-images/mine/7xgl) | Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in Apo form | 分子名称: | CHLORIDE ION, GLYCEROL, Quinolinate Phosphoribosyl Transferase, ... | 著者 | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | 登録日 | 2022-04-05 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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7XGN
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![BU of 7xgn by Molmil](/molmil-images/mine/7xgn) | Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in complex with Nicotinic Acid (NA) | 分子名称: | CHLORIDE ION, NICOTINIC ACID, Quinolinate Phosphoribosyl Transferase, ... | 著者 | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | 登録日 | 2022-04-05 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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7XGM
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![BU of 7xgm by Molmil](/molmil-images/mine/7xgm) | Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in complex with Quinolinic Acid (QA) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, QUINOLINIC ACID, ... | 著者 | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | 登録日 | 2022-04-05 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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8H89
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![BU of 8h89 by Molmil](/molmil-images/mine/8h89) | Capsid of Ralstonia phage GP4 | 分子名称: | Major capsid protein, Virion associated protein | 著者 | Liu, H.R, Chen, W.Y. | 登録日 | 2022-10-22 | 公開日 | 2022-11-16 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A Capsid Structure of Ralstonia solanacearum podoviridae GP4 with a Triangulation Number T = 9. Viruses, 14, 2022
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8XAR
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![BU of 8xar by Molmil](/molmil-images/mine/8xar) | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 54 | 分子名称: | 1,2-ETHANEDIOL, 7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ... | 著者 | Zheng, J.Y, Zhang, G.P, Li, J.J, Tong, S.L. | 登録日 | 2023-12-05 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy. J.Med.Chem., 67, 2024
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8XB0
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![BU of 8xb0 by Molmil](/molmil-images/mine/8xb0) | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 292 | 分子名称: | 1,2-ETHANEDIOL, 7-chloranyl-5-(2-cyclopropylpyridin-3-yl)-8-fluoranyl-2-methyl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ... | 著者 | Tong, S.L, Zhang, G.P. | 登録日 | 2023-12-05 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy. J.Med.Chem., 67, 2024
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6NKO
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![BU of 6nko by Molmil](/molmil-images/mine/6nko) | Crystal structure of ForH | 分子名称: | ForH | 著者 | Zheng, J, Irani, S, Zhang, Y. | 登録日 | 2019-01-07 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | 主引用文献 | Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis. J. Am. Chem. Soc., 141, 2019
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8JOV
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![BU of 8jov by Molmil](/molmil-images/mine/8jov) | Portal-tail complex of phage GP4 | 分子名称: | Portal protein, Putative tail fiber protein, Virion associated protein, ... | 著者 | Liu, H, Chen, W. | 登録日 | 2023-06-08 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers. J.Mol.Biol., 435, 2023
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8JOU
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![BU of 8jou by Molmil](/molmil-images/mine/8jou) | Fiber I and fiber-tail-adaptor of phage GP4 | 分子名称: | Virion-associated phage protein, rope protein of phage GP4 | 著者 | Liu, H, Chen, W. | 登録日 | 2023-06-08 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers. J.Mol.Biol., 435, 2023
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3DVD
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3DVB
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3DVC
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3DV7
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5V39
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7SLQ
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![BU of 7slq by Molmil](/molmil-images/mine/7slq) | Cryo-EM structure of 7SK core RNP with circular RNA | 分子名称: | 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Minimal circular 7SK RNA, ... | 著者 | Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. | 登録日 | 2021-10-24 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
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7SLP
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![BU of 7slp by Molmil](/molmil-images/mine/7slp) | Cryo-EM structure of 7SK core RNP with linear RNA | 分子名称: | 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Linear 7SK RNA, ... | 著者 | Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. | 登録日 | 2021-10-24 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
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2QJU
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![BU of 2qju by Molmil](/molmil-images/mine/2qju) | Crystal Structure of an NSS Homolog with Bound Antidepressant | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, LEUCINE, ... | 著者 | Zhou, Z, Karpowich, N.K, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2007-07-09 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science, 317, 2007
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5C3U
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![BU of 5c3u by Molmil](/molmil-images/mine/5c3u) | Crystal structure of a fungal L-serine ammonia-lyase from Rhizomucor miehei | 分子名称: | L-serine ammonia-lyase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Zhen, Q, Qiaojuan, Y, Shaoqing, Y, Zhengqiang, J. | 登録日 | 2015-06-17 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal structure and characterization of a novel l-serine ammonia-lyase from Rhizomucor miehei. Biochem.Biophys.Res.Commun., 466, 2015
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7MBO
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![BU of 7mbo by Molmil](/molmil-images/mine/7mbo) | FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR Milvexian (BMS-986177), IUPAC NAME:(6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6- oxopyrimidin-1(6H)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11- (metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa light chain, Milvexian | 著者 | Sheriff, S. | 登録日 | 2021-04-01 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.924 Å) | 主引用文献 | Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy. J.Med.Chem., 65, 2022
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6W50
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![BU of 6w50 by Molmil](/molmil-images/mine/6w50) | FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL ((10R,14S)- 14-(4-(3-CHLORO-2,6-DIFLUOROPHENYL)-6-OXO-3,6-DIHYDRO- 1(2H)-PYRIDINYL)-10-METHYL-9-OXO-8,16- DIAZATRICYCLO[13.3.1.0~2,7~]NONADECA-1(19),2,4,6,15,17- HEXAEN-5-YL)CARBAMATE | 分子名称: | 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... | 著者 | Sheriff, S. | 登録日 | 2020-03-12 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. J.Med.Chem., 63, 2020
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6DHA
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