3FSJ
 
 | | Crystal structure of benzoylformate decarboxylase in complex with the inhibitor MBP | | 分子名称: | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, Benzoylformate decarboxylase, CALCIUM ION | | 著者 | Brandt, G.S, Kenyon, G.L, McLeish, M.J, Jordan, F, Petsko, G.A, Ringe, D. | | 登録日 | 2009-01-09 | | 公開日 | 2009-01-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.
Biochemistry, 48, 2009
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2P8O
 | | Crystal Structure of a Benzohydroxamic Acid/Vanadate complex bound to chymotrypsin A | | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | | 著者 | Moulin, A, Bell, J.H, Pratt, R.F, Ringe, D. | | 登録日 | 2007-03-22 | | 公開日 | 2007-05-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Inhibition of chymotrypsin by a complex of ortho-vanadate and benzohydroxamic Acid: structure of the inert complex and its mechanistic interpretation.
Biochemistry, 46, 2007
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1BKH
 | | MUCONATE LACTONIZING ENZYME FROM PSEUDOMONAS PUTIDA | | 分子名称: | MUCONATE LACTONIZING ENZYME | | 著者 | Hasson, M.S, Schlichting, I, Moulai, J, Taylor, K, Barrett, W, Kenyon, G.L, Babbitt, P.C, Gerlt, J.A, Petsko, G.A, Ringe, D. | | 登録日 | 1998-07-07 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase.
Proc.Natl.Acad.Sci.USA, 95, 1998
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5T4J
 | | PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation | | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, HTH-type transcriptional regulatory protein GabR, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Wu, R, Sanishvili, R, Belitsky, B.R, Juncosa, J.I, Le, H.V, Lehrer, H.J.S, Farley, M, Silverman, R.B, Petsko, G.A, Ringe, D, Liu, D. | | 登録日 | 2016-08-29 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | | 主引用文献 | PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UOH
 | | Crystal Structure of Hip1 (Rv2224c) T466A mutant | | 分子名称: | Carboxylesterase A | | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Baikovitz, J, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | | 登録日 | 2017-01-31 | | 公開日 | 2017-04-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.609 Å) | | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
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1CM7
 | | 3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI | | 分子名称: | PROTEIN (3-ISOPROPYLMALATE DEHYDROGENASE) | | 著者 | Wallon, G, Kryger, G, Lovett, S.T, Oshima, T, Ringe, D, Petsko, G.A. | | 登録日 | 1999-05-17 | | 公開日 | 1999-07-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus.
J.Mol.Biol., 266, 1997
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5RHN
 | | HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP | | 分子名称: | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN | | 著者 | Brenner, C, Garrison, P, Gilmour, J, Peisach, D, Ringe, D, Petsko, G.A, Lowenstein, J.M. | | 登録日 | 1997-02-26 | | 公開日 | 1997-06-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.
Nat.Struct.Biol., 4, 1997
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5UGQ
 | | Crystal Structure of Hip1 (Rv2224c) | | 分子名称: | Carboxylesterase A | | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | | 登録日 | 2017-01-09 | | 公開日 | 2017-04-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.609 Å) | | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
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5UNO
 | | Crystal Structure of Hip1 (Rv2224c) | | 分子名称: | Carboxylesterase A | | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | | 登録日 | 2017-01-31 | | 公開日 | 2017-04-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
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1F5R
 | | RAT TRYPSINOGEN MUTANT COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR | | 分子名称: | CALCIUM ION, PANCREATIC TRYPSIN INHIBITOR, TRYPSIN II, ... | | 著者 | Pasternak, A, White, A, Cahoon, M, Ringe, D, Hedstrom, L. | | 登録日 | 2000-06-15 | | 公開日 | 2001-07-04 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
Protein Sci., 10, 2001
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2GMT
 | | THREE-DIMENSIONAL STRUCTURE OF CHYMOTRYPSIN INACTIVATED WITH (2S) N-ACETYL-L-ALANYL-L-PHENYLALANYL-CHLOROETHYL KETONE: IMPLICATIONS FOR THE MECHANISM OF INACTIVATION OF SERINE PROTEASES BY CHLOROKETONES | | 分子名称: | (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE, GAMMA-CHYMOTRYPSIN | | 著者 | Kreutter, K, Steinmetz, A.C.U, Liang, T.-C, Prorok, M, Abeles, R, Ringe, D. | | 登録日 | 1994-09-07 | | 公開日 | 1994-11-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones.
Biochemistry, 33, 1994
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1XQL
 | | Effect of a Y265F Mutant on the Transamination Based Cycloserine Inactivation of Alanine Racemase | | 分子名称: | (5-HYDROXY-4-{[(3-HYDROXYISOXAZOL-4-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Fenn, T.D, Holyoak, T, Stamper, G.F, Ringe, D. | | 登録日 | 2004-10-12 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Effect of a Y265F Mutant on the Transamination-Based Cycloserine Inactivation of Alanine Racemase
Biochemistry, 44, 2005
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1XQK
 | | Effect of a Y265F Mutant on the Transamination Based Cycloserine Inactivation of Alanine Racemase | | 分子名称: | (5-HYDROXY-4-{[(3-HYDROXYISOXAZOL-4-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Alanine racemase | | 著者 | Fenn, T.D, Holyoak, T, Stamper, G.F, Ringe, D. | | 登録日 | 2004-10-12 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Effect of a Y265F Mutant on the Transamination-Based Cycloserine Inactivation of Alanine Racemase
Biochemistry, 44, 2005
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2ACQ
 | | AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Harrison, D.H, Bohren, K.M, Gabbay, K.H, Petsko, G.A, Ringe, D. | | 登録日 | 1994-04-15 | | 公開日 | 1994-07-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.
Biochemistry, 33, 1994
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2NT0
 | | Acid-beta-glucosidase low pH, glycerol bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Glucosylceramidase, ... | | 著者 | Lieberman, R.L, Petsko, G.A, Ringe, D. | | 登録日 | 2006-11-06 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
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2NSX
 | | Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, GLYCEROL, ... | | 著者 | Lieberman, R.L, Petsko, G.A, Ringe, D. | | 登録日 | 2006-11-06 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
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2NT1
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2PRQ
 | | X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bacterial leucyl aminopeptidase, COBALT (II) ION | | 著者 | Munih, P, Moulin, A, Stamper, C.C, Bennet, B, Ringe, D, Petsko, G.A, Holz, R.C. | | 登録日 | 2007-05-04 | | 公開日 | 2007-06-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica.
J.Inorg.Biochem., 101, 2007
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2QQ9
 | | Crystal Structure of DtxR(D6A C102D) Complexed with Nickel(II) | | 分子名称: | Diphtheria toxin repressor, NICKEL (II) ION, PHOSPHATE ION | | 著者 | D'Aquino, J.A, Lattimer, J.R, Denninger, A, D'Aquino, K.E, Ringe, D. | | 登録日 | 2007-07-26 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Role of the N-Terminal Helix in the Metal Ion-Induced Activation of the Diphtheria Toxin Repressor DtxR.
Biochemistry, 46, 2007
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2QQA
 | | Crystal Structure of DtxR(E9A C102D) Complexed with Nickel(II) | | 分子名称: | Diphtheria toxin repressor, NICKEL (II) ION, PHOSPHATE ION | | 著者 | D'Aquino, J.A, Lattimer, J.R, Denninger, A, D'Aquino, K.E, Ringe, D. | | 登録日 | 2007-07-26 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Role of the N-Terminal Helix in the Metal Ion-Induced Activation of the Diphtheria Toxin Repressor DtxR.
Biochemistry, 46, 2007
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1QRZ
 | | CATALYTIC DOMAIN OF PLASMINOGEN | | 分子名称: | PLASMINOGEN | | 著者 | Peisach, E, Wang, J, de los Santos, T, Reich, E, Ringe, D. | | 登録日 | 1999-06-16 | | 公開日 | 1999-10-14 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the proenzyme domain of plasminogen.
Biochemistry, 38, 1999
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1QIR
 | | ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191Y MUTATION, WITH BOUND MALEATE | | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | | 登録日 | 1999-06-15 | | 公開日 | 2000-06-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase
Protein Eng., 13, 2000
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2A77
 | | Anti-Cocaine Antibody 7.5.21, Crystal Form II | | 分子名称: | GLYCEROL, Immunoglobulin Heavy Chain, Immunoglobulin Light Chain, ... | | 著者 | Pozharski, E, Hewagama, A, Shanafelt, A, Ringe, D, Petsko, G.A. | | 登録日 | 2005-07-04 | | 公開日 | 2005-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Flexibility of Packing: Four Crystal Forms of an Anti-Cocaine Antibody 7.5.21
To be Published
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1QIT
 | | ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191W MUTATION, WITH BOUND MALEATE | | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | | 登録日 | 1999-06-15 | | 公開日 | 2000-06-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase
Protein Eng., 13, 2000
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1QIS
 | | ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191F MUTATION, WITH BOUND MALEATE | | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | | 登録日 | 1999-06-15 | | 公開日 | 2000-06-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase
Protein Eng., 13, 2000
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