8IDT
 
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8INE
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8IDY
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8IPX
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8IR3
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8IPD
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8IR1
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8IPY
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8JJ2
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8JJ0
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8JIZ
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8JJ1
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8JSW
 | | Human VMAT2 complex with serotonin | | 分子名称: | SEROTONIN, Synaptic vesicular amine transporter | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-20 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8JTC
 | | Human VMAT2 complex with reserpine | | 分子名称: | Synaptic vesicular amine transporter, reserpine | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-21 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8JT9
 | | Human VMAT2 complex with ketanserin | | 分子名称: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-21 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8JTA
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7BP3
 | | Cryo-EM structure of the human MCT2 | | 分子名称: | Monocarboxylate transporter 2 | | 著者 | Zhang, B, Jin, Q, Zhang, X, Guo, J, Ye, S. | | 登録日 | 2020-03-21 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cooperative transport mechanism of human monocarboxylate transporter 2.
Nat Commun, 11, 2020
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7LUK
 | | CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692) IN COMPLEX WITH AN AZATRICYCLIC RORGT INVERSE AGONIST | | 分子名称: | (2S)-N-[(6aS,7R,9aS)-9a-[(4-fluorophenyl)sulfonyl]-3-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[f]quinolin-7-yl]-2-hydroxy-2-methyl-3-(methylsulfonyl)propanamide, Nuclear receptor ROR-gamma | | 著者 | Sack, J.S. | | 登録日 | 2021-02-22 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.087 Å) | | 主引用文献 | Azatricyclic Inverse Agonists of ROR gamma t That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
Acs Med.Chem.Lett., 12, 2021
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6XIE
 | | PCSK9(deltaCRD) in complex with cyclic peptide 77 | | 分子名称: | GLYCEROL, Peptide 77, Proprotein convertase subtilisin/kexin type 9 | | 著者 | Orth, P. | | 登録日 | 2020-06-19 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J.Med.Chem., 63, 2020
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8HGH
 | | Structure of 2:2 PAPP-A.STC2 complex | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION | | 著者 | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | | 登録日 | 2022-11-14 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | | 主引用文献 | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
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8HGG
 | | Structure of 2:2 PAPP-A.ProMBP complex | | 分子名称: | Bone marrow proteoglycan, Pappalysin-1, ZINC ION | | 著者 | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | | 登録日 | 2022-11-14 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
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6XIB
 | | PCSK9(deltaCRD) in complex with cyclic peptide 30 | | 分子名称: | GLYCEROL, Peptide 30, Proprotein convertase subtilisin/kexin type 9 | | 著者 | Orth, P. | | 登録日 | 2020-06-19 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.546 Å) | | 主引用文献 | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J.Med.Chem., 63, 2020
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6XID
 | | PCSK9(deltaCRD) in complex with cyclic peptide 51 | | 分子名称: | GLYCEROL, Peptide 51, Proprotein convertase subtilisin/kexin type 9 | | 著者 | Orth, P. | | 登録日 | 2020-06-19 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.482 Å) | | 主引用文献 | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J.Med.Chem., 63, 2020
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6XIC
 | | PCSK9(deltaCRD) in complex with cyclic peptide 40 | | 分子名称: | GLYCEROL, Peptide 40, Proprotein convertase subtilisin/kexin type 9 | | 著者 | Orth, P. | | 登録日 | 2020-06-19 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.377 Å) | | 主引用文献 | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J.Med.Chem., 63, 2020
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6XIF
 | | PCSK9(deltaCRD) in complex with cyclic peptide 83 | | 分子名称: | GLYCEROL, Peptide 83, Proprotein convertase subtilisin/kexin type 9 | | 著者 | Orth, P. | | 登録日 | 2020-06-19 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.774 Å) | | 主引用文献 | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J.Med.Chem., 63, 2020
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