7DGU
 
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7DMF
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7DKK
 | | De novo design protein XM2H | | 分子名称: | De novo design protein XM2H | | 著者 | Bin, H. | | 登録日 | 2020-11-24 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7DKO
 | | De novo design protein AM2M | | 分子名称: | de novo designed protein AM2M | | 著者 | Bin, H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7DGY
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7CI3
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7FBD
 | | De novo design protein D53 with MBP tag | | 分子名称: | Maltodextrin-binding protein,De novo design protein D53 | | 著者 | Bin, H. | | 登録日 | 2021-07-09 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7FBC
 | | De novo design protein D22 with MBP tag | | 分子名称: | Maltodextrin-binding protein,De novo design protein D22 | | 著者 | Bin, H. | | 登録日 | 2021-07-09 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7FBB
 | | De novo design protein D12 with MBP tag | | 分子名称: | Maltodextrin-binding protein,de novo designed protein D12 | | 著者 | Bin, H. | | 登録日 | 2021-07-09 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7F5F
 | | SARS-CoV-2 ORF8 S84 | | 分子名称: | CALCIUM ION, ORF8 protein | | 著者 | Chen, S, Zhou, Z, Chen, X. | | 登録日 | 2021-06-22 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.
Front Immunol, 12, 2021
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7F8L
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2H5E
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7C7P
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir | | 分子名称: | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | | 登録日 | 2020-05-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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8JBJ
 | | Crystal structure of anti-PVRIG Fab | | 分子名称: | antibody heavy chain, antibody light chain | | 著者 | Sun, J, Li, X.L, Song, J. | | 登録日 | 2023-05-09 | | 公開日 | 2023-06-21 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity.
Mabs, 15, 2023
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8JEL
 | | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I | | 分子名称: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | | 著者 | Sun, J, Zhang, X.X, Song, J. | | 登録日 | 2023-05-16 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEO
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8JEQ
 | | Crystal structure of Tiragolumab | | 分子名称: | antibody heavy chain, antibody light chain | | 著者 | Sun, J, Zhang, X.X, Song, J. | | 登録日 | 2023-05-16 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEN
 | | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II | | 分子名称: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | | 著者 | Sun, J, Zhang, X.X, Song, J. | | 登録日 | 2023-05-16 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEP
 | | Crystal structure of Ociperlimab | | 分子名称: | antibody heavy chain, antibody light chain | | 著者 | Sun, J, Zhang, X.X, Song, J. | | 登録日 | 2023-05-16 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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7D3I
 | | Crystal structure of SARS-CoV-2 main protease in complex with MI-23 | | 分子名称: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[3-[3,5-bis(fluoranyl)phenyl]propanoyl]-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase | | 著者 | Zeng, R, Li, Y.S, Qiao, J.X, Wang, Y.F, Yang, S.Y, Lei, J. | | 登録日 | 2020-09-19 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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7COM
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | | 分子名称: | 3C-like proteinase, boceprevir (bound form) | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | | 登録日 | 2020-08-04 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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6K2U
 | | Crystal structure of Thr66 ADP-ribosylated ubiquitin | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, MAGNESIUM ION, Polyubiquitin-C, ... | | 著者 | Wang, X, Zhou, Y, Zhu, Y. | | 登録日 | 2019-05-15 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | | 主引用文献 | Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination.
Mol.Cell, 78, 2020
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6IW5
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6IW1
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6IW4
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