4H3F
 
 | | Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile | | 分子名称: | 3-{5-[(2E,4aR,7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl}benzonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Strickland, C, Mandal, M. | | 登録日 | 2012-09-13 | | 公開日 | 2012-11-07 | | 最終更新日 | 2012-11-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation.
J.Med.Chem., 55, 2012
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4AQ3
 | | HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR | | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide | | 著者 | Bertrand, J.A, Fasolini, M, Modugno, M. | | 登録日 | 2012-04-12 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
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4H3G
 | | Structure of BACE Bound to 2-((7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)nicotinonitrile | | 分子名称: | 2-{(2E,4aR,7aR)-7a-[4-(3-cyanophenyl)thiophen-2-yl]-2-imino-3-methyl-4-oxooctahydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl}pyridine-3-carbonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Strickland, C, Mandal, M. | | 登録日 | 2012-09-13 | | 公開日 | 2012-11-07 | | 最終更新日 | 2012-11-21 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation.
J.Med.Chem., 55, 2012
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4H3J
 | | Structure of BACE Bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile | | 分子名称: | 2-fluoro-5-{5-[(2E,4aR,7aR)-2-imino-3-methyl-4-oxo-6-phenyloctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-2-yl}benzonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Strickland, C, Mandal, M. | | 登録日 | 2012-09-13 | | 公開日 | 2012-10-17 | | 最終更新日 | 2012-11-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation.
J.Med.Chem., 55, 2012
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5E92
 | | TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH AMPPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TGF-beta receptor type-2 | | 著者 | Sheriff, S. | | 登録日 | 2015-10-14 | | 公開日 | 2016-05-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.
Acta Crystallogr D Struct Biol, 72, 2016
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7MTB
 | | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 | | 分子名称: | Fab6 heavy chain, Fab6 light chain, RETINAL, ... | | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | | 登録日 | 2021-05-13 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
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7MT8
 | | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | | 登録日 | 2021-05-13 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
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7MTA
 | | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 | | 分子名称: | Fab1 Heavy chain, Fab1 Light chain, RETINAL, ... | | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | | 登録日 | 2021-05-13 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
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7MT9
 | | Rhodopsin kinase (GRK1) in complex with rhodopsin | | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | | 登録日 | 2021-05-13 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
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5E8S
 | | TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (WT) | | 分子名称: | TGF-beta receptor type-1 | | 著者 | Sheriff, S. | | 登録日 | 2015-10-14 | | 公開日 | 2016-05-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.
Acta Crystallogr D Struct Biol, 72, 2016
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5E8Z
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4H3I
 | | Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile | | 分子名称: | 3-{5-[(2E,4aR,7aR)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl}benzonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Strickland, C, Mandal, M. | | 登録日 | 2012-09-13 | | 公開日 | 2012-11-07 | | 最終更新日 | 2012-11-21 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation.
J.Med.Chem., 55, 2012
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7MUQ
 | | Reconstruction of the Legionella pneumophila Dot/Icm T4SS 3DVA Map 1 | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUV
 | | Reconstruction of the Legionella pneumophila Dot/Icm T4SS 3DVA Map 3 | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUY
 | | Reconstruction of the Legionella pneumophila Dot/Icm T4SS 3DVA Map 5 | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUD
 | | Legionella pneumophila Dot/Icm T4SS OMC | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUW
 | | Reconstruction of the Legionella pneumophila Dot/Icm T4SS 3DVA Map 4 | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUC
 | | Legionella pneumophila Dot/Icm T4SS C1 Reconstruction | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUS
 | | Reconstruction of the Legionella pneumophila Dot/Icm T4SS 3DVA Map 2 | | 分子名称: | DUF2807 domain-containing protein, DotC, DotD, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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7MUE
 | | Legionella pneumophila Dot/Icm T4SS PR | | 分子名称: | DotF, IcmE protein, Type IV secretion protein IcmK, ... | | 著者 | Sheedlo, M.J, Durie, C.L, Swanson, M, Lacy, D.B, Ohi, M.D. | | 登録日 | 2021-05-14 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
Elife, 10, 2021
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5ZXV
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5E8W
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4FLN
 | | Crystal structure of plant protease Deg2 | | 分子名称: | Protease Do-like 2, chloroplastic, Unknown peptide | | 著者 | Gong, W, Liu, L, Sun, R, Gao, F. | | 登録日 | 2012-06-15 | | 公開日 | 2012-09-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of Arabidopsis deg2 protein reveals an internal PDZ ligand locking the hexameric resting state.
J.Biol.Chem., 287, 2012
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5XMF
 | | Crystal structure of feline MHC class I for 2,1 angstrom | | 分子名称: | Beta-2-microglobulin, Gag polyprotein, MHC class I antigen alpha chain | | 著者 | Liang, R, Sun, Y, Wang, J, Wu, Y, Zhang, N, Xia, C. | | 登録日 | 2017-05-15 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
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5FIV
 | | STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR | | 分子名称: | RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | | 著者 | Li, M, Lee, T, Morris, G, Laco, G, Wong, C, Olson, A, Elder, J, Wlodawer, A, Gustchina, A. | | 登録日 | 1998-12-02 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
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